Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-11-02
2011-10-11
Woodward, Cherie M (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S013500, C514S013700, C530S350000, C536S023500
Reexamination Certificate
active
08034763
ABSTRACT:
The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d):(a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1;(b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity;(c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and(d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity,as an active component.
REFERENCES:
patent: 2003-116573 (2003-04-01), None
patent: 2004-121086 (2004-04-01), None
patent: 2004-121091 (2004-04-01), None
UniProt/KB/TrEBL Q7YT37 (Q7YT37—ANOST) (Mar. 1, 2004), Anti-platelet aggregation protein. Last accessed at: www.uniprot.org/uniprot/Q7YT37.html on Mar. 29, 2010.
UniProt/KB/TrEBL Q7YT37 (Q7YT37—ANOST) (Mar. 1, 2004).
Yasuo et al., JP 2003-116573 (Apr. 22, 2003) (English translation attached).
Jesus G. Valenzuela, et al, “Exploring the salivary gland transcriptome and proteome of theAnopheles stephensimosquito,” Insect Biochemisty and Molecular Biology (2003), vol. 33, No. 7, pp. 711-732.
Bruno Arca, et al, “An update catalogue of salivary gland transcripts in the adult female mosquito,Anopheles gambiae,” Journal of Experimental Biology (Oct. 2005), vol. 208, Pt. 20, pp. 3971-3986.
Jesus G. Valenzuela, et al, “Purification, Clothing, and Synthesis of a Novel Salivary Anti-thrombin from the MosquitoAnopheles albimanus,” Biochemistry (1999), vol. 38, No. 34, pp. 11209-11215.
J. M. C. Riberio, “Role of Mosquito Saliva in Blood Vessel Location,” Journal of Experimental Biology (1984), pp. 1-7.
S. Yoshida, et al, “Robust salivary gland-specific transgene expression inAnopheles stephensimosquito,” Insect Molecular Biology (2006), vol. 15, No. 4, pp. 403-410.
Watanabe, H. et al., “Cloning of a gene encoding for GE-rich protein of salivary gland ofAnaopheles stephensi,” Medical and Entomology and Zoology, (2004), vol. 55, Suppl., p. 41, Title No. 20.
H. Watanabe et al., “Cloning of a gene encoding for GE-rich protein of salivary gland ofAnopheles stephensi”, Medical and Entomology and Zoology, 2004, vol. 55, Suppl., p. 41, Title No. 20.
Database EMBL [online], “Anopheles stephensiansg-1 mRNA for GE rich salivary gland protein, complete cds”, Jul. 3, 2003.
S. Yoshida et al, “Robust salivary gland-specific transgene expression inAnopheles stephensimosquito”, Insect Molecular Biology, vol. 15, No. 4, pp. 403-410, 2006.
Shigeto Yoshida et al, “Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito”, Blood, vol. III, No. 4, pp. 2007-2014, 2008.
J. M. C. Ribeiro et al, “Role of MosquitoAedes-aegyptiSaliva in Blood Vessel Location”, Journal of Experimental Biology, vol. 108, pp. 1-8, 1984.
Sudo Toshiki
Yoshida Shigeto
Educational Foundation Jichi Medical University
Otsuka Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
Woodward Cherie M
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