Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-02-28
1986-05-13
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549 58, A61K 3138, C07D49508
Patent
active
045887411
ABSTRACT:
7-Thiabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal, glucamine salt or trihydroxymethylaminomethane salt, R.sup.1 is H (where X.noteq.O), lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, R.sup.2 is hydrogen or lower alkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
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"Thiosteroids-XXVII.sup.1 Steroidal Transannular 2.alpha.,5.alpha.-Episulphide-I. Synthesis of 5.alpha.-Cholestan-2.alpha.,5-Episulphide Derivatives", by Komeno et al., Tetrahedron, vol. 27, pp. 1503-1516.
E. R. Squibb & Sons Inc.
Jiles Henry R.
Levinson Lawrence S.
Mullins J. G.
Rodney Burton
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