Platelet aggregation inhibiting 2-oxyindoles, their compositions

Details Platelet aggregation inhibiting 2-oxyindoles, their compositions Platelet aggregation inhibiting 2-oxyindoles, their compositions

1977-06-15

1980-08-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032611R, 26032613R, C07D20904

Patent

active

042162203

ABSTRACT:
2-Oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.4 is --OR.sub.5, wherein R.sub.5 is selected from the group consisting of hydrogen, C.sub.1-8 alkyl, cyclohexyl, benzyl and phenethyl, or ##STR3## wherein R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.

REFERENCES:
patent: 3340266 (1967-09-01), Howe et al.
patent: 3509163 (1970-04-01), Brandstrom et al.
patent: 3514459 (1970-05-01), Ritter et al.
patent: 3749731 (1973-07-01), Zinnes et al.
patent: 3919239 (1975-11-01), Naragana et al.

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