Platelet aggregation inhibiting 2-oxyindoles, their compositions

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424250, 424263, 424270, 424274, 424267, 26032613R, 26032611R, 26032616, C07D20904

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active

043139477

ABSTRACT:
2-oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.

REFERENCES:
patent: 3860609 (1975-01-01), Lundt
patent: 4026897 (1977-05-01), Nakagawa et al.
patent: 4070470 (1978-01-01), Nakagawa et al.
patent: 4147869 (1979-04-01), Nakagawa et al.

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