Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-07-18
1982-02-02
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424263, 424270, 424274, 424267, 26032613R, 26032611R, 26032616, C07D20904
Patent
active
043139477
ABSTRACT:
2-oxyindole derivatives represented by the following general formula: ##STR1## where R.sub.1 is selected from the group consisting of hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, benzyl and phenethyl; A is --CH.dbd.CH-- or ##STR2## wherein R.sub.2 or R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1-4 alkyl; R.sub.6 and R.sub.7 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1-4 alkyl, benzyl, phenethyl and together with the nitrogen atom, a heterocyclic group selected from the group consisting of a piperidino, morpholino, piperazino or thiazolino group; and m and n each are zero or a positive integer with m+n being no more than 11. The 2-oxyindole derivatives have excellent effects on the inhibition of platelet aggregation.
REFERENCES:
patent: 3860609 (1975-01-01), Lundt
patent: 4026897 (1977-05-01), Nakagawa et al.
patent: 4070470 (1978-01-01), Nakagawa et al.
patent: 4147869 (1979-04-01), Nakagawa et al.
Nakagawa Kamuyuki
Oka Kimiaki
Uchida Minoru
Otsuka Pharmaceutical Co. Ltd.
Rizzo Nicholas S.
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