Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Digestive system
Patent
1989-06-20
1993-09-21
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Digestive system
424520, 530855, A61K 3557
Patent
active
052467155
ABSTRACT:
A composition of matter useful as an inhibitor of blood platelet aggregation, for the treatment of various clinical disorders such as thrombotic, inflammatory and immunological disorders. This composition of matter is derived from the saliva of leeches of the Hirudinidae family. The composition contains various components, all having molecular weights lower than 2,000 daltons. The composition has an inhibitory activity against platelet aggregation induced by various aggregating agents, including Platelet Activating Factor-acether (PAF-acether), arachidonic acid, thrombin, ADP and epinephrine.
REFERENCES:
Baskova, I. P.; Nikonov, G. I., "Antithrombotic effect of salivary gland retion and of other preparations from Hirudo medicinalis after intravenous and peroral administrations into rats.", Chemical Abstracts, 106 (No. 9): 39, Abstract No. 60996w (Mar. 2, 1987) and Vopr. Med. Khim., 32(6): 90-93 (1986) (Russ.).
Baskova, I. P.; Nikonov, G. I.; Mazurov, A. V.; Misselwitz, F.; Leitin, V. L.; Repin, V. S.; Avdonin, P. V.; Svitina-Ulitina, I. V., "Mechanisms of inhibition of vascular-platelet hemostasis by salivary gland scretion of the medicinal leech Hirudo medicinalis.", Chemical Abstracts, 107, (No. 23), Abstract No. 211673n (Dec. 7, 1987) and (Biokhimiya (Moscow) 52(9), 1461-8 (1987).
Baskova et al., Folia Haematol., 111, 831-7 (1984).
D. M. F. Cooper and M. Rodbell, Nature, 285:517-518 (1979).
M. L. Steer and A. Wood, J. Biol. Chem., 254:107931-10797 (1979).
Braquet, P. et al., Pharmacol. Rev., 39:97-145 (1987).
Orevi, M. et al., 15th International Congress of Biochemistry, Jerusalem, (abstract 1390) (1991).
Orevi, M. et al., Prostaglandins, 43:483-495 (1992).
"Platelet Aggregation Inhibitors in Hirudo medicinalis Leech Saliva: Partial Purification and Characterization by the Effect on Different Platelet Agonists", M. Orevi et al., Blood, 70, (No. 5), Suppl. 1, p. 357a (Nov. 1987).
Eldor Amiram
Orevi Miriam
Rigbi Meir
Robinson Douglas W.
Witz Jean C.
Yissum Research Development Company of the Hebrew University of
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