Platelet ADP receptor inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S231500, C514S292000, C514S293000, C514S309000, C544S009000, C544S125000, C544S126000, C546S081000, C546S082000, C546S083000, C546S141000, C546S142000

Reexamination Certificate

active

06906063

ABSTRACT:
Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3847925 (1974-11-01), Beregi et al.
patent: 5475025 (1995-12-01), Tjoeng et al.
patent: WO 94/19341 (1994-09-01), None
patent: WO 94/21602 (1994-09-01), None
patent: WO 99/36425 (1999-07-01), None
patent: WO 99/36425 (1999-07-01), None
patent: WO 01/57037 (2001-08-01), None
Plotnikova et al., “Arenesulfonamides, LXXX. Aroylarenesulfonamides”. Database CA Online! Chemical Abstracts Service, Columbus, OH, US, retrieved from STN Database Accession No. 82: 139564 XP002215531, abstract, &Vopr. Khim. Khim Tekhnol. (1974), 33, 20-5.

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