Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-08-01
2006-08-01
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S363000
Reexamination Certificate
active
07084142
ABSTRACT:
Compounds of the following formula:where m, n, R1, R2, R3, R4and R6are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
REFERENCES:
patent: 6861424 (2005-03-01), Bryant et al.
patent: 2003/0060474 (2003-03-01), Bryant et al.
patent: 739 886 (1996-10-01), None
patent: 1334705 (1973-10-01), None
patent: WO 92/08709 (1992-05-01), None
patent: WO 98/56771 (1998-12-01), None
Dullweber, F. et al., “Factorising Ligand Affinity: A Combined Thermodynamic and Crystallographic Study of Trypsin and Thrombin Inhibition,”J. Mol Biol. 313: 593-614, 2001.
Folts et al., “Platelet Aggregation in Partially Obstructed Vessels and its Elimination with Asprin,”Circulation 54(3):365-370, 1976.
Gachet et al., “Purinoceptors on Blood Platelets: Further Pharmaceutical and Clinical Evidence to Suggest the Presence of Two ADP Receptors,”British Journal Haematology. 91(2): 434-444, Oct. 1995.
Herbert et al., “Clopidogrel, A Novel Antiplatelet and Antithrombotic Agent,”Cardiovascular Drug reviews 11(2): 180-198, 1993.
Humphries et al., “Pharmacological Profile of the Novel P2T-Purinoceptor Antagonist, FPL 67085 in vitro and in the Anaesthrtized Rat in vivo,”British Journal of Pharmacology. 115(6): 1110-1116, Jul. 1995.
Kamm, W. et al., “Transport of Peptidomimetic Thrombin Inhibitors with 3-Amidino-Phyenylalanine Structure: Permeability and Efflux Mechanism in Monolayers of a Human Intestinal Cell Line (Caco-2),”Pharmaceutical Research 18(8): 1110-1118, 2001.
Kaslow and Marsh, “Substituted Bromoquinolines”J. Organic Chemistry 12(3):456-458, May 1947.
Mills, “ADP Receptor on Platelets,”Thrombosis Haemostasis 76(6):835-856, Dec. 1996.
Mustard et al., “Isolation of Human Platelets from Plasma by Centrifugation and Washing.”Methods Enzymology 169:3-11, 1989.
Pierce, A.C. and Jorgensen, W.L., “Estimation of Binding Affinities for Selecti e Thrombin Inhibitors via Monte Carlo Simulations,”J. Med. Chem. 44: 1043-1050, 2001.
Spath, “Zur Konstitution der Kynurensaure,”Monatshefte fur Chimie 42: 89-95, 1921.
Cornish, J. et al., “Trifuoroacetate, a Contaminant in Purified Proteins, Inhibits Proliferation of Osteoblasts and Chondrocytes,”Am J Pysiol Endocrinol Metab, 277: E779-E783, 1999.
Bryant Judi
Buckman Brad
Islam Imadul
Mohan Raju
Morrissey Michael
Larson Jacqueline S.
Schering Aktiengesellschaft
Washtien Wendy L.
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