Platelet activating factor antagonist and methods of use therefo

Details Platelet activating factor antagonist and methods of use therefo Platelet activating factor antagonist and methods of use therefo

1989-05-11

1990-11-27

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514822, A61K 3135

Patent

active

049736035

ABSTRACT:
6a,7,10,10a-tetrahydro-6,6-dimethyl-9-carboxyl-3-pentyl-6-H-dibenzo [b,d] pyran-1-ol is a potent antagonist to endogenous platelet activating factor (PAF). PAF is a factor in many of the pathological manifestations of disease, allergy or injury, such as inflammation, thrombosis and anaphylaxis. The actions of PAF can be inhibited in vivo by the present composition, thereby providing a safe and effective treatment for PAF-induced disorders.

REFERENCES:
Chem. Abst. 79:49530t, 1973.
Chem. Abst. 87:48575q, 1977.
Chem. Abst. 88:58994k, 1978.
Chem. Abst. 100:133678g, 100:133680b, and 100:133681c, 1984.
E. A. Formukong et al., J. Pharm. Pharmacol, 39(Suppl.): p. 79P (1987).
E. A. Formukong et al., Br. Journal of Pharmacol., 92 (Suppl.): p. 601P (1987).
S. Burstein et al., Biochem. Pharmacol., 35(15):2553-2558 (1986).
R. S. Wilson et al., J. Medical Chemistry, 18(7):700-703 (1975).
H. M. Bhargava, Gen. Pharmacol., 9(4):195-213 (1978).
D. Heiden et al., Thrombosis Res., 17:885-889 (1980).
J. F. Rivas et al., Eur. J. Pharmacol., 65:317-318 (1980).
H. DeSousa et al., Japan J. Pharmacol., 28:507-510 (1978).
F. H. Chilton et al., Journal of Biological Chemistry, 257:5402-5407 (1982).
P. Braquet et al., Pharmacol. Revs., 392:97-145 (1987).
R. Mechoulam et al., Experimentia, 29:1193-1195 (1973).
W. Calhoun et al., Agents and Actions, 21:306-309 (1987).
J. M. Young et al., Prostaglandins, 30(4):545-551 (1985).

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