Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1995-06-06
1996-07-02
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352402, 4352523, 4353201, 536 232, 536 235, C12N 918, C12N 1555, C12N 510, C12N 115
Patent
active
055321526
ABSTRACT:
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.
REFERENCES:
patent: 5019508 (1991-05-01), Johnson et al.
patent: 5279957 (1994-01-01), Gross
Stafforini et al, "Human Plasma Platelet-activating Factor Acetylhydrolase" J. Biol. Chem. 262(9):4223-4230 (Mar. 1987).
Stafforini et al, "The Platelet-activating Factor Acetylhydrolase from Human Erythrocytes", J. Biol. Chem. 268(6):3857-3865 (Feb. 1993).
Brenner, "The Molecular Evolution of Genes and Proteins: A Tale of Two Serines", Nature, 334:528-530 (1988).
Capecchi, "Altering the Genome by Homologous Recombination", Science, 244:1288-1292 (1989).
Chapus et al., "Minireview on pancreatic lipase and colipase", Biochemie, 70:1223-1224 (1988).
Denizot et al., "PAF-Acether and Acetylhydrolase in Stool of Patients with Crohn's Disease", Digestive Diseases and Sciences, 37(3):432-437 (1992).
Handley et al., "Platelet Activating Factor and Inflammation in Atherogenesis: Targets for Drug Development", Drug Dev. Res., 7:361-375 (1986).
Hattori et al., "Purification and Characterization of Bovine Brain Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 268(25):18748-18753 (1993).
Heuer et al., "Current status of PAF antagonists", Clin. Exp. Allergy, 22:980-983 (1992).
Kald et al., "Release of Platelet-Activating Factor in Acute Experimental Pancreatitis", Pancreas, 8(4):440-442 (1993).
Lindsberg et al., "Evidence for Platelet-Activating Factor as a Novel Mediator in Experimental Stroke in Rabbits", Stroke, 21:1452-1457 (1990).
Lindsberg et al., "Platelet-activating Factor in Stroke and Brain Injury", Ann Neurol., 30:117-129 (1991).
Matsuzaki et al., "PAF acetylhydrolase activities in human systemic lupus erythematosus and lupus-pronemice", Clinica Chimica Acta, 210:139-144 (1992).
Mezzano et al., "Detection of Platelet-Activating Factor in Plasma of Patients With Streptococcal Nephritis", J. Am. Soc. Nephrol., 4:235-242 (1993).
Miwa et al., "Characterization of Serum Platelet-activating Factor (PAF) Acetylhydrolase", J. Clin. Invest., 82:1983-1991 (1988).
Rabinovici et al., "Platelet Activating Factor Mediates Interleukin-2-induced Lung Injury in the Rat", J. Clin. Invest., 89:1669-1673 (1992).
Satoh et al., "Platelet-activating Factor (PAF) Stimulates the Production of PAF Acetylhydrolase by the Human Hepatoma Cell Line, HepG2", J. Clin. Invest., 87:476-481 (1991).
Satoh et al., "Platelet-Activating Factor Acetyhydrolase in Plasma Lipoproteins From Patients with Ischemic Stroke", Stroke, 23:1090-1092 (1992).
Stafforini et al., "Human Macrophages Secrete Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 265(17):9682-9687 (1990).
Stremler et al., "Human Plasma Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 266(17):11095-11113 (1991).
Tarbet et al., "Liver Cells Secrete the Plasma Form of Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 266(25):16667-16673 (1991).
Venable et al., "Platelet-activating factor: a phospholipid autacoid with diverse actions", J. Lipid Res., 34:691-701 (1993).
Wada et al., "Codon Usage Tabulated from the GenBank Genetic Sequence Data", Nuc. Acids Res., 19S:1981-1986 (1991).
Zarco et al., "Involvement of platelet-activating factor and tumour necrosis factor in the pathogenesis of joint inflammation in rabbits", Clin. Exp. Immunol., 88:318-323 (1992).
Stafforini et al., "Platelet-Activating Factor Acetylhydrolase Activity in Human Tissues and Blood Cells", Lipids, 26(12):979-985 (1991).
Cousens Lawrence S.
Eberhardt Christine D.
Gray Patrick
Tjoelker Larry W.
Trong Hai
ICOS Corporation
Walsh Stephen G.
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