Platelet-activating factor acetylhydrolase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 71, 435 72, 435 79, 530300, 5303881, 514 2, C12N 914

Patent

active

056416695

ABSTRACT:
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.

REFERENCES:
Stafforini et al. JBC 262: 4223-4230 1987.
Tarbet et al JBC 266: 16667-16673 1990.
Adjei and Garren, "Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers", Pharm. Res., 7(6):565-569 (1990).
Braquet et al., "Effect of Endothelin-1 on Blood Pressure and Bronchopulmonary System of the Guinea Pig", J. Cardio. Pharm., 13(Supp. 5):S143-S146 (1989).
Brenner, "The molecular evolution of genes and proteins: a tale of two serines", Nature, 334:528-530 (Aug. 11, 1988).
Capecchi, "Altering the Genome by Homologous Recombination", Science, 244:1288-1292 (Jun. 16, 1989).
Chapus et al., "Minireview on pancreatic lipase and colipase", Biochimie, 70:1223-1224 (1988).
deBoer et al., "The tac promoter: A functional hybrid derived from the trp and lac promoters", Proc. Natl. Acad. Sci. USA, 80:21-25 (Jan. 1983).
Debs et al., "Lung-Specific Delivery of Cytokines Induces Sustained Pulmonary and Systemic Immunomodulation in Rats", J. Immunol., 140(10):3462-3488 (May 15, 1933).
Denizot et al., "PAF-Acether and Acetylhydrolase in Stool of Patients with Crohn's Disease", Digestive Diseases and Sciences, 37(3):432-437 (Mar. 1992).
Furukawa et al., "Platelet-Activating Factor-Induced Ischemic Bowel Necrosis: The Effect of Platelet-Activating Factor Acetylhydrolase", Ped. Res., 34(2):237-241 (1993).
Grino et al., "BN 52021: A Platelet Activating Factor Antagonist for Preventing Post-Transplant Renal Failure", Anna. Int. Med., 121(5):345-347 (Sep. 1, 1994).
Handley and Saunders, "Platelet Activating Factor and Inflammation in Atherogenesis: Targets for Drug Development", Drug. Dev. Res., 7:361-375 (1986).
Hattori et al., "Purification and Characterization of Bovine Brain Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 268(25):18748-18753 (Sep. 5, 1993).
Hattori et al., "The Catalytic Subunit of Bovine Brain Platelet-activating Factor Acetylhydrolase Is a Novel Type of Serine Esterase", J. Biol. Chem., 269(37):23150-23155 (Sep. 16, 1994).
Henriques et al., "Endothelin-1 inhibits PAF-induced paw oedema and pleurisy in the mouse", Br. J. Pharmacol., 106:579-582 (1992).
Heuer, "Current status of PAF antagonists", Clin. Exp. Allergy, 22:980-983 (1992).
Hoffman et al., "Detection of platelet-activating factor in amniotic fluid of complicated pregnancies", Am. J. Obstet. Gynecol., 162(2):525-528 (1990).
Horwitz et al., "DNA sequences of the araBAD-araC controlling region in Salmonella typhimurium LT2", Gene, 14:309-319 (1981).
Hsieh and Ng, "Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy", J. Allergy Clin. Immunol., 91:650-657 (Feb. 1993).
Hsueh et al., "Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis", Acta P524 diatr., Suppl. 396:11-17 (1994).
Hubbard et al., "Anti-Neutrophil-Elastase Defenses of the Lower Respiratory Tract in .alpha.1-Antitrypsin Deficiency Directly Augmented with an Aerosol of A1-Antitrypsin", Annals of Internal Medicine, III(3):206-212 (Aug. 1, 1989).
Kald et al., "Release of Platelet-Activating Factor in Acute Experimental Pancreatitis", Pancreas, 8(4):440-442 (1993).
Kurosawa et al., "Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms", Allergy, 49:60-63 (1994).
La Vallie et al., "A Thioredoxin Gene Fusion Expression System That Circumvents Inclusion Body Formation in the E. coli Cytoplasm", Bio/Technology, 11:187-193 (Feb. 11, 1993).
Lewin, pp. 136-141 in Genes V, Oxford University Press, New York, New York (1994).
Lindsberg et al., "Evidence for Platelet-Activating Factor as a Novel Mediator in Experimental Stroke in Rabbits", Stroke, 21(10):1452-1457 (Oct. 1990).
Lindsberg et al., "Platelet-activating Factor in Stroke and Brain Injury", Ann. Neurol., 30(2):117-129 (Aug. 1991).
Maki et al., "Platelet-activating factor acetylhydrolase activity in maternal, fetal, and newborn rabbit plasma during pregnancy and lactation", Proc. Natl. Acad. Sci. USA, 85:728-732 (Feb. 1988).
Matsumoto et al., "Platelet-Activating Factor in Bronchoalveolar Lavage Fluid of Patients With Adult Respiratory Distress Syndrome", Clin. Exp. Pharmacol. Physiol., 19:509-515 (1992).
Matsuzaki et al., "PAF acetylhydrolase activities in human systemic lupus erythematosus and lupus-prone mice", Clinica Chimica Acta, 210:139-144 (1992).
Mezzano et al., "Detection of Platelet-Activating Factor in Plasma of Patients with Streptococcal Nephritis", J. Am. Soc. Nephrol., 4:235-242 (1993).
Miwa et al., "Characterization of Serum Platelet-activating Factor (PAF) Acetylhydrolase", J. Clin. Invest., 82:1983-1991 (Dec. 1988).
Rabinovici et al., "ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats", J. Appl. Physiol., 74(4):1791-1802 (1993).
Rabinovici et al., "Platelet Activating Factor Mediates Interleukin-2-induced Lung Injury in the Rat", J. Clin. Invest., 89:1669-1673 (May 1992).
Rodriguez-Roisin et al., "Platelet-activating Factor Causes Ventilation-Perfusion Mismatch in Humans", J. Clin. Invest., 93:188-194 (Jan. 1994).
Satoh et al., "Platelet-activating Factor (PAF) Stimulates the Production of PAF Acetylhydrolase by the Human Hepatoma Cell Line, HepG2", J. Clin. Invest., 87:476-481 (Feb. 1991).
Satoh et al., "Platelet-Activating Factor Acetylhydrolase in Plasma Lipoproteins From Patients With Ischemic Stroke", Stroke, 23:1090-1092 (1992).
Smith et al., "Pulmonary Deposition and Clearance of Aerosolized Alpha-1-Proteinase Inhibitor Administered to Dogs and to Sheep", J. Clin. Invest., 84:1145-1154 (Oct. 1989).
Stafforini et al., "Human Macrophages Secrete Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 265(17):9682-9687 (Jun. 15, 1990).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhdrolase: Association with lipoprotein particles and role in the degradation of platelet-activating factor", J. Biol. Chem., 262(9):4215-4222 (Mar. 25, 1987).
Stafforini et al., "Human Plasma Platelet-activating Factor Acetylhydrolase: Purification and Properties", J. Biol. Chem., 262(9):4223-4230 (Mar. 25, 1987).
Stafforini et al., "Platelet-activating factor acetylhydrolase activity in human tissues and blood cells", LIPIDS, 26(12):979-985 (1991).
Stafforini et al., "The Platelet-activating Factor Acetylhydrolase from Human Erythrocytes: Purification and Properties", J. Biol. Chem., 268(6):3857-3865 (Feb. 25, 1993).
Stafforini et al., "Lipoproteins alter the catalytic behavior of the platelet-activating factor acetylhydrolase in human plasma", Proc. Natl. Acad. Sci., 86:2393-2397 (Apr. 1989).
Stremler et al., "Human Plasma Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 266(17):11095-11103 (Jun. 15, 1991).
Tarbet et al., "Liver Cells Secrete the Plasma Form of Platelet-activating Factor Acetylhydrolase", J. Biol. Chem., 266(25):16667-16673 (Sep. 1991).
Venable et al., "Platelet-activating factor: a phospholipid autacoid with diverse actions", J. Lipid Res., 34:691-701 (1993).
von Heijne, "A new method for predicting signal sequence cleavage sites", Nuc. Acids Res., 14(11):4683-4690 (1986).
Wada et al., "Codon Usage tabulated from the GenBank Genetic sequence data", Nuc. Acids Res., 19S:1981-1986 (1991).
Watanabe et al., "Pharmacological analysis of neutrophil chemtactic factor production by leucocytes and roles of PAF in allergic inflammation in rats", Br. J. Pharmacol., 111:123-130 (1994).
Watson et al., "The Platelet-Activating Factor Antagonist Web 2170 Its Beneficial Effect on Dog Renal Allograft Survival", Transplantation, 56(4):1047-1049 (Oct. 1993).
Zarco et al., "Involvement of platelet-act

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Platelet-activating factor acetylhydrolase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platelet-activating factor acetylhydrolase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platelet-activating factor acetylhydrolase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-148642

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.