Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-02-20
1992-06-09
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546273, 546184, C07D40314, C07D40114, A61K 3140
Patent
active
051207494
ABSTRACT:
Indole compounds substituted at the 1- or 3 position by a (pyrid-3 yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl) dithiolan-4-ol)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
REFERENCES:
patent: 4273782 (1981-06-01), Cross et al.
patent: 4786645 (1988-11-01), Fabre et al.
patent: 4948795 (1990-08-01), Mase et al.
May Paul D.
Phillips James G.
Pireh Daisy
Sheppard George S.
Steinman Douglas H.
Abbott Laboratories
Janssen Jerry F.
Rotman Alan L.
Schmidt Twordzik Barbara
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