Special receptacle or package – For mixing – Tear strip or piercer
Patent
1982-09-28
1989-01-17
Fidei, David T.
Special receptacle or package
For mixing
Tear strip or piercer
206219, 206632, B65D 2508
Patent
active
047982888
DESCRIPTION:
BRIEF SUMMARY
OBJECT OF THE INVENTION
One of the objects of the present invention relates to the industrial production of an inexpensive packing which is ready for use (unit dose) for pharmaceutical, insecticide cosmetic or other chemical products of various types, which packing is designed to contain at least two substances which cannot be left in contact for long periods and which must therefore be mixed just before use.
BACKGROUND OF THE INVENTION
Numerous pharmaceutical or chemical active substances are preferably used in the form of solutions or mixtures with other ingredients or excipients. However, in practice, many of these active substances are less stable in solution than in their solid state, or even incompatible with certain of the other ingredients or additives of the solution in question. This is due, in particular, to the fact that when these mixtures are heated, for example during a sterilization process, or kept for long periods, they give rise to chemical reactions which render their constituents completely inactive or at least substantially decrease their activity.
In the case of a number of clinical infusion solutions, it has proved advantageous to use combinations of glucose and amino acids of various types. The drawback, which is at present difficult to overcome, of these combinations lies in the incompatibility of the products when they are heated, and in particular in the case of sterilization. The aldehyde group of the glucose in effect reacts with the free amino groups of the amino acids such as lysine (Maillard reaction) leading to the formation of Schiff bases which are the cause, inter alia, of the dark colouring of these solutions. This type of reaction does not only lead to modification of the physical aspect of these solutions, but also has a detrimental effect on biological compatibility, thus making the solutions completely unsuitable for infusion.
One of the solutions proposed as a remedy for these drawbacks consists in replacing, in sterilizable mixtures for infusion, glucose by sorbitol, as this latter product does not have an aldehyde group. However, sorbitol has several drawbacks which limit its use from the legal point of view.
If use is made, on the other hand, of packings having multiple compartments in accordance with the invention, it is possible to sterilize and keep the glucose and amino acid solutions separately. The internal portion of the joint common to both compartments in question is broken, just before use, under the action of an external pressure, for example a finger pressure, and the two solutions may then be immediately contacted and mixed.
A device which has recently been developed for the perfuming of rooms comprises a sachet of specially adapted polymer material containing a perfuming solution (see, in this respect, the International Appl. WO 81/00051). The perfume vapours diffuse slowly through the wall of polymer material and may thus perfume the room for a long period. A problem arises, however, during the storage of these devices before sale. As a result of the diffusion of the perfume vapours through the walls of polymer material of the packing, a considerable reduction in the initial amount of active substances may be observed.
SUMMARY OF THE INVENTION
By using packings having multiple compartments of the invention, this drawback may be readily overcome. The perfuming solution is maintained in a compartment having walls which cannot be permeated by the perfume vapours and wherein one of the joints may be ruptured under the action of external pressure, then, when the walls of the joint have been broken, just before use, the solution passes into a compartment having walls of polymer material which may be permeated by the perfume vapours which may then be diffused in a uniform manner into the surrounding atmosphere.
The present invention relates to a plastic packing having multiple compartments for liquid and solid products, characterised in that it contains a joint which is common to both compartments constituted by at least two sheets of polymer mat
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Fidei David T.
Firmich SA
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