Plastic film bag lyophilization system

Details Plastic film bag lyophilization system Plastic film bag lyophilization system

1984-12-31

1986-09-02

Sipos, John

Special receptacle or package

Combined or convertible

206525, 34 5, 426106, 426111, 426112, 426385, 426394, 426402, 53432, 53433, B65D 8118

Patent

active

046091025

ABSTRACT:
A plastic film bottom tray is held in shape by a rigid bottom rim. A plastic film top is held in shape by a rigid top rim above the tray. Substance to be lyophilized is frozen in the tray. The assembly is lyophilized in a vacuum chamber. Apertures formed between the top and the tray provide fluid pathways for efficient sublimation. After dehydration, the top rim is pushed down into the bottom rim, obliterating the apertures and pressure sealing the two films together in-vacuo.
After removal from the vacuum chamber, the two films are heat sealed together, forming a lyophilized product vacuum sealed within a plastic film bag. Rims and film beyond the heat seal are trimmed away.

REFERENCES:
patent: 3715853 (1973-02-01), Bemiss
patent: 3950919 (1976-04-01), Perdue
patent: 4058953 (1977-11-01), Sanborn et al.
patent: 4223513 (1980-09-01), Mahaffy et al.
patent: 4286389 (1981-09-01), Ogle
patent: 4342183 (1982-08-01), Gordon et al.

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