Plaster with a supply of a medically active substance

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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Details

604 87, 604306, 604307, 206441, D24189, A61M 3700, A61K 970, A61F 1302

Patent

active

057361533

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

This is a National Stage Application under 35 USC 371 of PCT/NL/00216, filed Oct. 26, 1993.
The invention relates to a plaster, comprising: adhere to the skin, membrane, for example at least partially embedded therein, in which capsule a supply of a medically active substance is contained which, through breaking of the membrane, can be absorbed into the cushion for contact with and gradual delivery to the skin;


BACKGROUND OF THE INVENTION

Such a plaster is known from DE-A-37 21 595. The plaster known from this prior art specification comprises breaking means designed as relatively complicated three-dimensional structures shaped such that by exerting a pressure substantially vertically on the outer surface, a sharp edge forming part of the three-dimensional structure is pressed downward to break a closing membrane, thus releasing the medically active substance from the capsule.
It is a purpose of the invention to embody the plaster such that it does not require the use of relatively complicated three-dimensional structures.


SUMMARY OF THE INVENTION

The present invention comprises a porous cushion and at least one adhesive edge with which the plaster can adhere to the skin; membrane, for example at least partially embedded therein, in which capsule a supply of a medically active substance is contained which, through breaking of the membrane, can be absorbed into the cushion for contact with and gradual delivery to the skin; and
Thereto the plaster of the invention is characterized in that said breaking means comprise two places adjacent to the membrane and mutually adjoining with at least partially complementary edges, which plates can be pressed toward one another by a user, whereby the plates hinge mutually relative to the edges and at least one of the edges breaks the membrane. It should be noted that the plates define substantially one main plate and do not form part of the capsule itself, contrary to the teachings of DE-A-37 21 595.
After arranging the plaster on the skin through adhesive attachment by means of the adhesive edge, the user can release the medically active substance by pressing the plates toward one another, whereby they undergo a hinge movement and are in a position to break the membrane. Through breaking of this membrane the active substance can be absorbed into the cushion. This cushion can then deliver the substance to the skin.
In order to cause the breaking of the membrane to take place with the greatest possible certainty the plaster can have the feature in a preferred embodiment that at least one of the edges has a sharp protrusion.
In particular this plaster can display the feature that at least one of the edges has a zigzag shape with pointed extremities.
A very practical and simple embodiment, in which the correct mutual positioning of the plates is automatically ensured, is that in which the plates are mutually joined via a weakening line, which weakening line is situated between the complementary edge parts. In this case the weakening line can preferably be embodied such that it is a score line which is situated on the side of the plates remote from the capsule. Thus is additionally ensured, insofar as still necessary, that the hinge movement of the plates of the breaking edges takes place such that the membrane is broken. It is noted that after adhering the plaster to the skin the plates can only move outwardly relative to the skin, namely the direction of the least resistance.
In order to cause the steady dosing of the medically active substance to take place as effectively as possible a particular embodiment is characterized by a gauze extending over the free surface of the cushion to be directed towards the skin. This gauze encloses spaces in which the medically active substance can be temporarily stored in order to be delivered gradually to the skin. Depending on the application of the plaster it can be recommended to choose for this gauze a material which does not adhere to the skin or to a wound. Polypropylene for example can be a suitable

REFERENCES:
patent: 2817336 (1957-12-01), Kravitz et al.
patent: 3580254 (1971-05-01), Stuart
patent: 4018357 (1977-04-01), Ostrem
patent: 4117841 (1978-10-01), Perotta et al.
patent: 4693711 (1987-09-01), Bremer et al.
patent: 4808172 (1989-02-01), Murata et al.

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