Optics: measuring and testing – Refraction testing – Prism forming fluid specimen container
Reexamination Certificate
2007-09-18
2007-09-18
Punnoose, Roy M. (Department: 2886)
Optics: measuring and testing
Refraction testing
Prism forming fluid specimen container
Reexamination Certificate
active
11090583
ABSTRACT:
Detection apparatus for performing surface plasmon resonance (SPR) measurements on a sample includes a support having side walls and a bottom wall defining a plurality of adjacent wells. The bottom wall has integrated therein SPR detectors underlying the wells for detecting the refractive indexes of samples deposited in the wells. Each SPR detector includes a prism having an exterior entrance surface, an exterior exit facet and an interior sensing surface located at the bottom of the overlying well, and a thin metal layer coated on the sensing surface. The prism may be molded from a transparent polymer into the bottom of a standard-format microplate structure. That structure may be used in conjunction with an SPR measuring or reading instrument to perform label-less assay measurements on various samples in an efficient and reliable manner. A method of acquiring the assay measurements is also disclosed.
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Cesari & McKenna LLP
Perkinelmer LAS, Inc.
Punnoose Roy M.
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