Plasmodium proteins useful for preparing vaccine compositions

Details Plasmodium proteins useful for preparing vaccine compositions Plasmodium proteins useful for preparing vaccine compositions

1997-09-12

2000-09-19

Navarro, Mark

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241911, 4242681, 4242721, 530300, 530324, 530325, 530326, 530327, 530328, 530329, 530350, A61K 3900, A61K 39002, A61K 39015, C07K 100

Patent

active

061207705

ABSTRACT:
The present invention relates to DNA segments encoding MAEBL, an erythrocyte binding protein of a Plasmodium parasite, to substantially pure MAEBL proteins and to recombinantly or synthetically produced MAEBL molecules. The MAEBL proteins can be utilized as a vaccine for humans against malaria.

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Peterson, D.C., Miller, L.H. and Wellems, T.E., "Isolation of multiple sequences from the Plasmodium falciparumgenome that encode conserved domains homologous to those in erythrocyte binding proteins" Proc. Natl. Acad. Sci. USA, vol. 92, pp. 7100-7104,1995.
Aikawa, M., Miller, L.H., Johnson, J. and Rabbege, Jr., "Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite", J. Cell Biol., vol. 77, pp. 72-82, 1978.
Sim, B.K., Orlandi, P.A., Haynes, J.D., Klotz, F.W., Carter, J.M., Camus, D., Zegans, M.E. and Chulay, J.D., "Primary structure of 175K Plasmodium falciparum erythrocyte binding antigen and identification of a peptide which elicits antibodies that inhibit malaria merozoite invasion", J. Cell Biol., vol. 111, pp. 1877-1884, 1990.

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