Plasmodium merozoite rhoptries antigenic polypeptides

Details Plasmodium merozoite rhoptries antigenic polypeptides Plasmodium merozoite rhoptries antigenic polypeptides

1994-11-16

1996-08-06

Mosher, Mary E.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 43525233, 43525411, 435 693, 4352402, 536 231, 536 237, 935 65, C12N 1530, C12N 121, C12N 113, C12N 510

Patent

active

055433235

ABSTRACT:
Novel antigenic polypeptides having at least one determinant immunologically cross-reactive with determinants on a polypeptide associated with the rhoptry organelles of the merozoite form of the malaria parasite Plasmodium falciparum are described. Also described are immunogenic compositions containing such a polypeptide, DNAs coding for such a polypeptide, recombinant vectors containing such a DNA sequence, host organisms containing a replicable vector, and antibodies which are directed against a polypeptide in accordance with the invention. In addition, processes for the production of the immunogenic compositions, the microorganisms, and the antibodies, as well as the use the polypeptides and the immunogenic compositions for the immunization of mammals against malaria are also described.

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