Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1993-08-20
1995-02-28
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
514 2, 514 12, 435 693, 530324, 530350, 530395, 530855, 4242681, A61K 3566, A61K 39015
Patent
active
053935233
ABSTRACT:
Recombinant histidine-rich protein of Plasmodium falciparum, its preparation and use. It was possible, by screening two different Plasmodium falciparum cDNA gene banks with an antiserum against a 41 kD protein and by cross-hybridization with the insert DNA of a clone obtained therewith, to isolate a gene which codes for a Histidine-Alanine-rich protein (HRP-II). This protein protects aotus monkeys from infection with P. falciparum and is thus a suitable constituent of a malaria vaccine.
REFERENCES:
patent: 4721617 (1988-01-01), Johnson
patent: 5130416 (1992-07-01), Wellems
Groux et al., "Functional Characterization of the Antibody-Mediated Protection Against Blood Stages of Plasmodium falciparum in the Monkey Saimiri sciureus", Eur. J. Immunol., 20:2317-2323 (1990).
Gysin et al., "Characterization by Anti-Ig-Monoclonal Antibodies of Protective and Non-Protective Antibodies Against Asexual Forms of Plasmodium falciparum in the Saimiri Monkey", Ann. Inst. Pasteur/Immunol., 138:829-844 (1987).
Knapp et al., "A New Blood Stage Antigen of Plasmodium falciparum Transported to the Erythrocyte Surface", Molecular and Biochemical Parasitology, 37:47-56 (1989).
"Role of non-human primates in malaria vaccine development: Memorandum from a WHO Meeting", Bulletin of the WHO, 66:719-728 (1988).
Patarroyo et al., "Induction of Protective Immunity Against Experimental Infection . . . ", Nature, 328:629-632 (1987).
Patarroyo et al., "A Synthetic Vaccine Protects Humans Against Challenge with Asexual Blood . . . ", Nature, 332:158-161 (1988).
Lenstra et al., "Cloning and Sequencing of Plasmodium falciparum DNA Fragments . . . ", Biochemical and Biophysical Res. Comm., 146:368-377 (1987).
H. D. Stahl et al., Nucl. Acids. Res., 13, (1985), pp. 7837-7846.
T. Maniatis et al., Molecular Cloning, A Laboratory Manual, (1982), Table of Contents.
H. Kupper et al., Proceedings of the Fourth International Symposium of Genetics of Industrial Microorganisms, (1982), pp. 222-226.
F. Sanger et al., Proc. Natl. Acad. Sci., 74, (1977), pp. 5463-5467.
T. Huynh et al., DNA Cloning, vol. 1, (1985), pp. 49-78.
K. Strebel et al., J. of Virology, 57, (1985), pp. 983-991.
A. M. Maxam et al., Meth. Enzymol, 65, (1980), pp. 499-560.
G. Pasvol et al., Ann. Trop. Med. Parasitol, 72, (1978), pp. 87-88.
C. Lambros et al., J. Parasitol, 65, (1979), pp. 418-420.
W. Trager et al., Science, 193, (1976), pp. 673-675.
E. Remaut et al., Gene, 22, (1983), pp. 103-113.
L. H. Perrin et al., J. Clin. Invest., 75, (1985), pp. 1718-1721.
A. Cheung et al., The EMBO Journal, 4, (1985), pp. 1007-1012.
R. J. Howard et al., J. Cell. Biol., 103, (1986), pp. 1269-1277.
T. Wellems et al., Proc. Natl. Acad. Sci., 83, (1986), pp. 6065-6069.
Godson, G. N., Scientific American, May 1985, Molecular Approaches to Malaria Vaccines.
Enders Burkhard
Hundt Erika
Knapp Bernard
Kupper Hans
Behringwerke Aktiengesellschaft
Cunningham Thomas
Nucker Christine M.
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