Plasmodium falciparum merozoite antigen peptides

Details Plasmodium falciparum merozoite antigen peptides Plasmodium falciparum merozoite antigen peptides

1988-03-14

1993-08-24

Ellis, Joan

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435693, 435 91, 4351723, 4352351, 4353201, 43525233, 4352582, 536 27, 530350, 935 12, 935 29, 935 41, 935 56, 935 65, 935 72, C12P 2102, C12P 1934, C12N 1500, C12N 700, C12N 121, C12N 116, C12N 118, C07H 1512, C07K 300

Patent

active

052388360

ABSTRACT:
The present invention provides polypeptides having an amino acid sequence derived from the 190 kD precursor to the major merozoite surface antigens of the K1 isolate of Plasmodium falciparum. These polypeptides are capable of eliciting an immune response against different isolates of Plasmodium falciparum. The invention further provides immunogenic compositions and vaccines containing such polypeptides, antibodies raised against the polypeptides. a DNA sequence coding for one of the polypeptides, a replicable microbial vector containing such a DNA sequence and a microorganism transformed with such a vector. The invention also provides processes for the production of the polypeptides, immunogenic compositions, microorganisms and antibodies of the invention and for the use of the polypeptides and immunogenic compositions for the immunization of mammals against malaria.

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