Plasmodium falciparum AMA-1 protein and uses thereof

Details Plasmodium falciparum AMA-1 protein and uses thereof Plasmodium falciparum AMA-1 protein and uses thereof

2006-06-13

2006-06-13

Smith, Lynette R. F. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S268100, C435S069100, C435S069300, C435S069700, C435S071200, C435S235100, C435S320100, C435S070100, C435S070200, C536S023500, C536S023700, C536S024320

Reexamination Certificate

active

07060276

ABSTRACT:
In this application is described the expression and purification of a recombinantPlasmodium falciparum(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

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