Plasmodium falciparum AMA-1 protein and uses thereof

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Reexamination Certificate

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C424S268100, C424S265100, C424S199100, C424S190100, C424S185100, C530S350000, C536S023700, C435S320100, C435S173300, C435S069300

Reexamination Certificate

active

07029685

ABSTRACT:
In this application is described the expression and purification of a recombinantPlasmodium falciparum(3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.

REFERENCES:
patent: 5766597 (1998-06-01), Paoletti et al.

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