Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Enzyme inactivation by chemical treatment
Reexamination Certificate
2006-07-04
2006-07-04
Tate, Christopher R. (Department: 1654)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Enzyme inactivation by chemical treatment
C435S217000, C424S094640, C514S002600, C514S012200, C514S013800, C530S324000, C530S325000
Reexamination Certificate
active
07070969
ABSTRACT:
The invention provides novel single stage competitive inhibitors of plasmin from the Australian brown snakePseudonaja textilis textilis. The invention also features polynucleotides and polynucleotide homologues encoding these inhibitors. Pharmaceutical compositions containing the plasmin inhibitors of the invention are also disclosed as well as methods useful for treatment of blood loss.
REFERENCES:
patent: WO-99-58569 (1999-11-01), None
Willmott et al. Fibrinolysis 1995, vol. 9, pp. 108.
Fibrinolysis, vol. 9, No. 1, 1995, Willmot et al, A Novel Serine Protease Inhibitor from the Australian Brown Snake,Pseudonaja textilis textilis: Inhibition Kinetics, pp. 1-8.
P.P. Masci, “The Effects of Australian Snake Venoms on Coagulation and Fibrinolysis”,Thesis163 pages Jul. 1986, Univ of Queensland, St. Lucia, Brisbane, Australia.
Fibrinolysis, vol. 9, No. 1, 1995, N. Willmot et al, “A Novel Serine Protease Inhibitor from the Australian Brown Snake,Pseudonaja textilis textilis: Inhibition Kinetics,” pp. 1-8.
Gaffney Patrick Joseph
Lavin Martin Francis
Masci Pantaleone Paul
Chism B. Dell
Foley & Lardner LLP
National Institute of Biological Standards and Control
Tate Christopher R.
The University of Queensland
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