Plasmin A-chain urokinase B-chain hybrid protein

Details Plasmin A-chain urokinase B-chain hybrid protein Plasmin A-chain urokinase B-chain hybrid protein

1988-03-25

1989-11-14

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530363, 530403, 530807, 530811, 435212, 435215, 435217, 424 9464, 424 942, C12N 968, C12N 972, A61K 3754, A61K 37547

Patent

active

048807761

ABSTRACT:
A hybrid protein which comprises plasmin A-chain linked to urokinase B-chain, the catalytic site of which is blocked by a removable blocking group.

REFERENCES:
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patent: 4507283 (1985-03-01), Smith
patent: 4545988 (1985-10-01), Nakayama et al.
patent: 4600580 (1986-07-01), Smith
patent: 4752581 (1988-06-01), Robinson et al.
Summaria et al., J. Biol. Chem., vol. 254, pp. 6811-6814, 1979.
Robbins et al, Biochemistry, vol. 25, pp. 3603-3611, Jun. 1986.
Jackson et al, Biochem., 1982, 21, 6620-6625.
D. Collen et al, Thromb Haemostas (Stuttgart), 52 (1), 24-26, 1984.
Fuchs et al, Blood, vol. 65, No. 3 (Mar.), 1985; pp. 539-544.
Nakayama et al, "The Plasmin Heavy Chain-Urokinase Conjugate: A Specific Thrombolytic Agent", Throm and Haem, 56 (3), 361-370 (1986).
Robbins et al, "Covalent Molecular Weight 292,000 Hybrid Plasminogen Activator Derived From Human Plasmin Amono-Terminal and Urokinase Carboxyl-Terminal Domains", Biochemistry, vol. 25, No. 12, pp. 3603-3611 (1986).
Summaria et al, J. Biol. Chem., 251, No. 18, 5810-5813 (1976).

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