Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1989-01-27
1991-10-01
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
43525233, 4353201, 935 29, 935 60, 935 73, C12N 984, C12N 121, C12N 1570
Patent
active
050533355
ABSTRACT:
The present invention provides a plasmid suitable for the expression of penicillin G amidase, wherein it carries an incomplete penicillin G amidase gene in which the first 78 bases of the translated region on the 5' end of the complete gene are missing. This incomplete penicillin G amidase gene can also be present incorporated in the form of two separate fragments which commence with bases 79 and 868, respectively, counting from the translated region on the 5' end of the gene and displaying a deletion of the coding bases 705 to 867.
The present invention also provides a process for the production of these plasmids and is also concerned with the use thereof for obtaining penicillin G amidase.
REFERENCES:
patent: 4554250 (1985-11-01), McCullough
Burtscher et al., "Folding, Assembly, Stability and Genetic Modification of Penicillin Acylase and Its Precursor", Poster Presented at the "Biotechnology Action Program Final Meeting", Nov. 14-18, 1989, Troia, Portugal.
Bock, A. et al. (1983), FEMS Microbiol. Lett. 20, 135-139, 141-144.
Buckel Peter
Schumacher Gunter
Boehringer Mannheim GmbH
Patterson Charles L.
Weimar Elizabeth C.
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