Plasmid having temperature dependent plasmid copy number

Details Plasmid having temperature dependent plasmid copy number Plasmid having temperature dependent plasmid copy number

1980-12-08

1984-12-11

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Miscellaneous

935 29, 935 43, 4351723, C12N 100, C12N 1500

Patent

active

044878354

ABSTRACT:
Gene products of plasmid DNA, such as proteins, are prepared in high yields by cultivating bacteria carrying a plasmid which shows a controlled constant plasmid copy number at one temperature and a much higher or totally uncontrolled copy number at a different temperature. The plasmid may be prepared by recombinant DNA technique using a cloning vector showing the temperature dependent plasmid copy number pattern.

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