Plasmid entrapping multilamellar liposomes

Details Plasmid entrapping multilamellar liposomes Plasmid entrapping multilamellar liposomes

1997-03-14

1998-04-28

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4351723, 4353201, 514 44, A61K 9127, A61K 4800, C12N 1563

Patent

active

057441596

ABSTRACT:
A plasmid entrapping multilamellar liposome for introducing a gene into cells, which liposome has constitutive lipids of N-(.alpha.-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG); dioctanoylphosphatidyl choline (DOPC) or didecanoylphosphatidyl choline (DDPC); and dioleoylphosphatidyl ethanolamine (DOPE) or dilauroylphosphatidyl ethanolamine (DLPE) and in a molar ratio of 1:2-3:2-1 in case of lipid combination of TMAG, DOPC and DOPE, or 1:2:2 in case of lipid combination of TMAG, DDPC or DOPC and DLPE.

REFERENCES:
patent: 4921706 (1990-05-01), Roberts et al.
patent: 5552157 (1996-09-01), Yagi et al.

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