Plasmid encoding canine BMP-7

Details Plasmid encoding canine BMP-7 Plasmid encoding canine BMP-7

2006-11-14

2009-10-06

Wilson, Michael C. (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

07598364

ABSTRACT:
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.

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Zhu, W., et al.: Combined Bone Morphogenetic Protein-2 and -7 Gene Transfer Enhances Osteoblastic Differentiation and Spine Fusion in a Rodent Model; wwvv.JBMR-online.com, vol. 19, No. 12 (2004) p. 1-13.
Li, T., et al.: Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease; Curr Opin Nephrol Hypertens 13: 417-422 (2004).
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