Plasmid-based vaccine for treating atherosclerosis

Details Plasmid-based vaccine for treating atherosclerosis Plasmid-based vaccine for treating atherosclerosis

2005-01-25

2005-01-25

Nguyen, Dave T. (Department: 1632)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S320100, C435S455000, C424S130100

Reexamination Certificate

active

06846808

ABSTRACT:
A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of CETP and one or more broad range helper T cell epitopes. Administration of the plasmids as a vaccine to a vertebrate subject provides an immune response to the subject's endogenous CETP and modulation of CETP activity, leading to prevention or reversal of various manifestations of heart disease. The vaccines provide an advantageous strategy for the prevention or treatment of atherosclerosis.

REFERENCES:
patent: 5242687 (1993-09-01), Tykocinskli et al.
patent: 5338829 (1994-08-01), Weiner et al.
patent: 5705388 (1998-01-01), Couture et al.
patent: 0343 460 (1989-11-01), None
patent: WO 9015627 (1990-12-01), None
patent: WO 9210203 (1992-06-01), None
patent: WO 9311782 (1993-06-01), None
patent: WO 9323076 (1993-11-01), None
patent: WO 9424567 (1994-10-01), None
patent: WO 9425060 (1994-11-01), None
patent: WO 9639168 (1996-12-01), None
Gordon (The New England J of Medicine, vol. 321, 19, pp 1311-1316, 1989).*
Luc et al (Sang Trombose Vaisseuax vol. 94 pp 206-212).*
Assmann et al of Cardiovascular Pharmacology, 16 Suppl. 9 (S15-S20) 1991.*
Stedronsky, Biochimica et Biophysica Acta—Lipids and Lipid Metabolism, 1210/3, 255-287, 1994.*
McNamara, Biochimica et Biophysica Acta 1529, 2000, 310-320.*
Stein (Athercsclerosis, 145, pp. 285-301. 1999).*
Hayek et al., J. Clin. Invest. 96, pp 2071-2074 1995.*
Inazu et al., N. Engl. M. Med., 323 1234-1238. 1990.*
Zhong et al., J. Clin Invest, 97:2917-2923. 1996.*
Hirano et al., Arterioscler. Thromb. Vasc. Biol., 17:1053-1059, 1997.*
Kunitake et al. J. Lipid Res. 33:1807-1816 1992.*
Newnham et al., Biochim. Biophysis. Acta, 1044:57-64, 1990.*
Foger et al., The J. of Biological Chemistry, vol. 274 52:36912-36920. 1999.*
Yamashita et al., Atherosclerosis. 152 271-285 2000.*
McCluskie et al. (Molecular Medicine. 5. pp. 287-300. 1999).*
Shih et al. (Molecular Medicine Today, 1, 8, pp. 364-372 1995).*
Feldman et al. (J. Clinical Investigation. 95. 6. 2662-71. 1995).*
Verma et al. (Nature vol. 389 18 239-242 Sep. 1997).*
Anderson. Nature vol. 392 25 30 1998.*
Luc et al (Database Embase AN 97251152 Sang Trombose Vaisseuax vol. 94. pp 206-212) states (abstract).*
Hirano Arterioscler Thromb Vasc Biol. 17 1053-1059. 1997.*
Ada, G.L.,Fundamental Immunology, 3rd ed., pp. 1309-1352 (W. E. Paul, ed.) (Raven Press. Ltd., New York, 1993).
Agellon, L.B. et al.,J. Biol. Chem., 266: 10796-10801 (1991).
Aitken, R.J. et al.,Brit. Med. Bull., 49: 88-99 (1993).
Albers et al.,Arteriosclerosis. 4: 49-58 (1984).
Alexander et al.,Immunity, 1: 751-761 (1994).
Barter et al,J. Lipid Res., 21: 238-249 (1980).
Bevilacqua et al.,J. Clin. Invest., 91: 379-387 (1993).
Bisgaier et al.,J. Lipid Res., 32: 21-23 (1991).
Bisgaier et al.,J. Lipid Res., 34: 1625-1634 (1993).
Breslow et al.,Proc. Natl. Acad. Sci. USA, 90: 8314-8318 (1993).
Brown et al.,Nature, 342: 448-451 (1989).
Carlson et al.,Biochem. J., 173: 723-737 (1978).
Casali et al.,Science, 234: 476-479 (1986).
Castelli et al.,J. Am. Med. Assoc., 256: 2835-2838 (1986).
Current Protocols in Immunology, pp. 3.11.1-3.11.15, 3.12.1-3.12.14 (Coligan, J.E. et al., eds.) (John Wiley & Sons, New York, 1994);.
Drayna et al.,Nature, 327: 632-634 (1987).
Eldridge et al., inImmunobiology of Proteins and Peptides V: Vaccines; Mechanisms, Design, and Applications, Atassi, M.Z., ed. (Plenum Press, New York, 1989), pp. 191-202.
Engelhard, Victor H., Sci. Am., 54-60 (1994).
Etlinger et al.,Science, 249: 423-425 (1990).
Etlinger, H.,Immunol. Today, 13: 52-55 (1992).
Farmer, J.A. et al.,Heart Disease. A Textbook of Cardiovascular Medicine, 4th ed., pp. 1125-1160 (Braunwald, E., ed.) (W. B. Saunders Co., Philadelphia, 1992).
Fielding et al.,J. Lipid Res., 36: 211-228 (1995).
Gavish et al.,J. Lipid Res., 28: 257-267 (1987).
Gaynor et al.,Atherosclerosis, 110: 101-109 (1994).
Genetic Engineering News, 14: 44 (Aug. 1994).
Gordon et al.,N. Engl. J. Med., 321: 1311-1316 (1989).
Groener, J.E.M. et al.,Biochim. Biophys. Acta, 1002: 93-100 (1989).
Green et al.,Cell, 28: 477-487 (1982).
Ha et al.,Biochim. Biophys. Acta, 833: 203-211 (1985).
Ha et al.,Comp. Biochem. Physiol., 83B: 463-466 (1986).
Havel et al., “Introduction: Structure and metabolism of plasma lipoproteins”, InThe Metabolic Basis of Inherited Disease, 6th ed., pp. 1129-1138 (Scriver, et al., eds.) (McGraw-Hill, Inc., New York, 1989).
Hayek et al,J. Clin. Invest., 90: 505-510 (1992).
Hayek et al.,J. Clin. Invest., 91: 1665-1671 (1993).
Hesler et al.,J. Biol. Chem., 262: 2275-2282 (1987).
Hesler et al.,J. Biol. Chem., 263: 5020-5023 (1988).
Ikewaki, et al.,J. Clin. Invest., 96: 1573-1581 (1995).
Inazu et al.,N. Engl. J Med., 323: 1234-1238 (1990).
Jarnagin et al.,Proc. Natl. Acad. Sci USA, 84: 1854-1857 (1987).
Jiang et al.,J. Biol. Chem., 266: 4631-4639 (1991).
Jiang et al.,J. Biol. Chem., 268: 27406-27412 (1993).
Kligfield et al.,Am. Heart J.,112(3): 589-597 (1986).
Korn et al.,J. Mol. Biol., 65: 525-529 (1972).
Kotake et al.,J. Lipid Res., 37: 599-605 (1996).
Kushwaha et al.,J. Lipid Res, 34: 1285-1297 (1993).
Mabuchi, H. et al.,Annals N.Y. Acad. Sci., 748: 333-341 (1995).
Madden et al.,Ann. Rev. Immunol., 13: 587-622 (1995).
Mader, S.S., InHuman Biology, 4th ed., pp. 83, 102 (Wm. C. Brown Publishers, Dubuque, Iowa, 1995).
Marguerite et al.,Mol. Immunol., 29: 793-800 (1992).
Marotti et al.,Nature, 364: 73-75 (1993).
Mathews, C.K. and van Holde, K.E.,Biochemistry, pp. 574-576, 626-630 (The Benjamin/Cummings Publishing Co., Redwood City, California, 1990).
Means and Feeney,Bioconjugate Chem., 1: 2-12 (1990).
Mezdour et al.,Clin. Chem.40/4: 593-597 (1994).
Miller et al.,Am. Heart J., 113: 589-597 (1987).
Nagashima et al.,J. Lipid Res., 29: 1643-1649 (1988).
Nelson et al.,J. Clin. Invest., 91: 1157-1166 (1993).
Palker et al.,Proc. Natl. Acad. Sci. USA, 84: 2479-2483 (1987).
Panina-Bordignon et al.,Eur. J. Immunol., 19: 2237-2242 (1989).
Pruitt et al.,J. Surg. Res., 50: 350-355 (1991).
Pruitt et al.,Transplantation, 52: 868-873 (1991).
Quig et al.,Ann. Rev. Nutr., 10: 169-193 (1990).
Quinet et al.,J. Clin. Invest., 85: 357-363 (1990).
Raju et al.,Eur. J. Immunol., 25: 3207-3214 (1995).
Rosen et al.,J. Immunol. Methods, 172: 135-137 (1994).
Rye et al.,J. Biol. Chem, 270: 189-196 (1995).
Sad et al.,Immunol., 76 599-603 (1992).
Stern et al.,Nature, 368 215-221 (1994).
Suckling, Keith E.,Bio/Technology, 12: 1379-1380 (1994).
Swenson et al.,J. Biol. Chem., 263: 5150-5157 (1988).
Swenson et al.,J. Biol. Chem.. 264: 14318-14326 (1989).
Tall, A.R..J. Clin. Invest., 89: 379-384 (1990).
Tall, A.R.,J. Lipid Res., 34: 1255-1274 (1993).
Tall, A.R.,J. Internal Med., 237: 5-12 (1995).
Talwar et al., Proc. Natl. Acad. Sci. USA, 91: 8532-8536 (1994).
Tam, J.P.,Proc. Natl. Acad. Sci. USA, 85: 5409-5413 (1988).
Tao et al.,Nature, 362: 755-758 (1993).
Tato et al.,Arterioscler, Thromb, Vascular Biol., 15: 112-120 (1995).
The Merck Manual of Diagnosis and Therapy, 16thed., (Merck & Company Inc., Rahway, New Jersey, 1992), pp. 22-23 (referring to infection prevention), pp. 114-115 (referring to bacterial diseases), pp. 1944-1947 (referring to health management of neonates, infants, and children);
Travis,Science, 262: 1974-1975 (1993).
Valmori et al.,J. Immunol., 149: 717-721 (1992).
Wang et al.,Science, 254: 285-288 (1991).
Wang et al.,J. Biol. Chem., 267: 17487-17490 (1992).
Wang et al.,J. Biol. Chem., 268: 1955-1959 (1993).
Wang et al.,J. Biol. Chem., 270: 612-618 (1995).
Watanabe et al.,Proc. Natl. Acad. Sci. USA, 89: 5103-5107 (1992).
Watson et al.,Molecular Biology of the Gene, 4th ed., (The Benjamin/Cummings Publishing Company, Inc., Menlo Park, California, 1987), p. 836.
Wedrychowski et al.,Biotechnology, 11(4): 486-489 (1993).
Weisman et al.,Science, 249: 146-151 (1990).
Whitlock et al,J. Clin. Invest., 84: 129-137 (1989).
Yeh et al.,J. Immunol., 146: 250-256 (1991).
Yen et al.,J. Clin. Invest., 83: 2018-2024 (1989).
Zannis et al., “Genetic mutations affecting human lipoproteins, their receptors, and their enzymes”, InAdvances in Human Ge

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