Plasmapheresis system and method

Details Plasmapheresis system and method Plasmapheresis system and method

1985-04-12

1987-12-15

Sever, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210782, 2103211, 2104332, 210927, 21032168, B01D 1300, B01D 2126

Patent

active

047131764

ABSTRACT:
A reliable flow rate plasmapheresis system includes a rotating enhanced vortex of membrane filter coupled to receive a flow of anticoagulated whole blood and separate concentrate and filtrate in response thereto. An anticoagulant pump is coupled to mix controlled amounts of anticoagulant with the input blood flow. Degradation of plasma flow rate during multiple extraction-reinfusion cycles is inhibited by selecting the starting anticoagulant pH value and controlling the anticoagulant flow rate relative to the whole blood to establish a final whole blood/plasma pH value in the range of 6.8 to 7.2, with an anticoagulant to blood ratio in the range of 1:6 to 1:25.

REFERENCES:
patent: 3634228 (1972-01-01), Latham
Lopez-Leiva, "Ultrafiltration at Low Degrees of Concentration Polarization: Technical Possibilities", Dec. 80, pp. 210-651.
Dorson, Int. App. WO82/03567, 10-1982.
Forstron et al, "Formed Element Deposition onto Filtering Walls", Trans. Am. Soc. Artif. Int. Organs, vol. XXI (1975) (pp. 602-607(.

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