Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-09-09
1998-10-27
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 179, A61K 3170, C07H 1500
Patent
active
058278303
ABSTRACT:
An isolated plasmalopsychosine selected from the group consisting of compound A and compound B: ##STR1## wherein n1 is 0-50 or an isolated synthetic plasmalocerebroside selected from the group consisting of compound C and compound D: ##STR2## wherein n2 and n3 each is 0-50.
REFERENCES:
patent: 4284763 (1981-08-01), Thelwall et al.
patent: 4544552 (1985-10-01), Fraefel et al.
J.C. Samson, "Gangliosides (Cronassial) as therapeutic agents in peripheral neuropathies" Drugs of Today (1986) 22: No. 2 pp. 73-107.
G. Zubay, Biochemistry (1983) pp. 581-583.
A. Veinberg et al., "Selective Protection of Hydroxyl Groups . . . " Chemical Abstracts (1971) 74: 54148a.
C.E. Ballou & A. Dell, "Polysaccharide-Lipid Interaction Analyzed by Fast-atom bombardment Mass Spectometry" Carbohydrate Research (1985) 140: 131-143.
L.G. Bennett & C.T. Bishop, "Structure of the Type XXVII Streptococcus . . . " Can J. Chem. (1977) 55: 8-16.
H. Bjorndal et al., "Gas-Liquid Chromatography and Mass Spectrometry . . . Polysaccharides" Angew. Chem. Intl. Ed. Eng. (1970) 9: 610-619.
I. Ciucanu & F. Kerek, "A Simple and Rapid Method for Permethylation of Carbohydrates" Carbohydrate Research (1984) 131: 209-217.
E.J. Corey & G. Schmidt, "Useful Procedures for the Oxidation of Alcohols Involving . . . Media" Tetrahedron Lett. (1979) 5: 399-402.
B. Domon & C.E. Costello, "Structure Elucidation of Glycosphingolipids and Gangliosides . . . Spectrometry" Biochemistry (1988) 27: 1534-1543.
J. Folch et al., "Isolation of Brian Strandin, A New Type of Large Molecule Tissue Component" J. Biol. Chem. (1951) 191: 819-831.
I. Fujii et al., "An Easy and Powerful Technique of Negative Ion Fast . . . Matrix" J. Soc. Chem. Commun. (1985) pp. 405-406.
P.A. Gorin & T. Ishikawa, "Configuration of Pyruvic Acid Ketals, 4,6-0-Linked to D-galactose Units . . . Polysaccharides" Can J. Chem. (1967) 45: 521-532.
Y.A. Hannun & R.M. Bell, "Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses", Science (1987) 235: 670-674.
Y.A. Hannun & R.M. Bell, "Functions of Sphingolipid and Sphingolipids Breakdown Products in Cellular Regulation", Science (1989) 243: 500-507.
A. Hara & T. Taketomi, "Chemical Properties and Steroisomerism of Heterogeneous . . . Spectroscopy" J. Biochem. (Tokyo) (1986) 100: 415-423.
M.E. Hemling et al., "Fast Atom Bombardment Mass Spectrometry of . . . Sugars", Biochemistry (1984) 23: 5706-5713.
S. Hirase, "Studies on the Chemical Constitution of Agar-agar. XIX Pyruvic Acid . . . Agar" Bull. Chem. Soc. Japan (1957) 30: 68-70.
R. Isobe et al., "Direct Microznalysis by Negative Ion Fast Atom Bombardment Mass Spectometry" Trends in Anal. Chem. (1987) 6: 78-81.
U. Kikkawa et al., "Rapid Purification of Protein Kinase C by High Performance Liquid Chromatography" Biochem. Biophys. Res. Commun. (1986) 135: 636-643.
Y. Kishimoto et al., "6-Acyl Galactosyl Ceramides of Pig Brain: Structure and Fatty Acid Composition" J. Lipid Res. (1968) 9: 27-33.
E. Klenk & Debuch, "Plasmalogens", Prog. Chem. Fats Lipids (1963) 6: 1-29.
N.K. Kochetkov et al., "Table II--The Effects of ATP and Coenzyme A on the Acylation of Lysophospatidylinositol" Biochim. Biophys. Acta (1962) 60: 431-432.
N.K. Kochetkov et al., "Sphingoplasmalogens. A New Type of Sphingolipids" Biochem. Biophys Acta (1963) 70:716-719.
M. Kubota & T. Taketomi, "Minor Glycolipids Being Less Polar Than Cerebroside in Porcine Spinal Cord" Jap. J. Exp. Med. (1974) 44: 145-150.
R.A. Laine et al., "Gas-Liquid Chromatography of Carbohydrates" Meth. Enzymol. (1963) 28: 159-167.
G. Larson et al., "Application of a Simple Methylation Procedure for the . . . Glycosphingolipids" Carbohydrate Research (1987) 161: 281-290.
A.H. Merrill & V.L. Stevens, "Modulation of Protein Kinase C and Diverse Cell Functions by Sphingosine--a Pharmacologically . . . Transduction" Biochim. Biophys. Acta (1989) 1010: 131-139.
T. Miyatake & K. Suzuki, "Globiod Cell Leukodystrophy: Additional . . . Galactosidase" Biochem. Biophys. Res. Commun. (1972) 48: 538-543.
S. Neuenhofer et al., "Occurrence of Lysoganglioside . . . Brain" Biol. Chem. Hoppe-Seyler (1986) 367: 241-244.
G.A. Nores et al., "Synthesis and Characterization of . . . Compounds" Carbohydrates Research (1988) 179: 393-410.
W.T. Norton & M. Brotz, "New Galactolipids of Brain: A Monoalkyl-monoacyl-glycerol . . . Esters" Biochem. Biophys. Res. Commun. (1963) 12: 198-203.
Y. Ohashi et al., "Analysis of Long-chain Bases in Sphingolipids by Positive . . . Spectometry" Biochemistry (1987) 26: 3390-3395.
M.M. Rapport & R.E. Franzl, "The Structure of Plasmalogens-III. The Nature and Significance of . . . Linkage" J. Neurochem. (1957) 1: 303-310.
M.M. Rapport et al., "The Struture of Plasmalogens. II. Crystalline . . . Phospholipide)" J. Biol. Chem. (1957) 225: 859-867.
C.C. Sweeley et al., "Gas-Liquid Chromatography of Trimethylsilyl Derivatives . . . Substances" J. Am. Chem. Soc. (1963) 85: 2497-2507.
Y. Tamai, "Further Study on the Faster Running Glycolipid in Brain" Jap. J. Exp. Med. (1968) 38: 65-73.
Y. Tamai et al., "New Glycolipids in Bovine Brain" Jap. J. Exp. Med. (1967) 37: 79-81.
J.B. Wittenberg et al., "The Determination of Higher Fatty Aldehydes in Tissues" J. Biol. Chem. (1956) 219: 39-47.
R.K. Yu & R.W. Ledeen, "Gangliosides of Human, Bovine and Rabbit Plasma" J. Lipid Res. (1972) 13: 680-686.
R. Feulgen & K. Voit, "Uber Einen weitverbreiteten festen Aldehyde" Pfluger's Archiv fue die Gesampte Physiologie (1924) 206: 389-410.
R. Feulgen et al., "Zur Kenntnis des Plasmalogens" Hoppe-Seyler's Z. Physiol. Chem. (1929) 180: 161-180.
Feulgen & Grunberg, "Quantitative Bestimmung des Plasmals (Plasmalogens) in Lipoiden Gemischen und in Organen" Hoppe-Seyler's Z. Physiol. Chem. (1938) 257: 161-172.
R. Fuelgen & T. Bersin, "Zur Kenntnis des Plasmalogens" Hoppe-Seyler's Z. Physiol. Chem. (1939) 260: 217-245.
H. Debuch & M. Winterfeld, "Uber die Struktur der C.sub.18 -und C.sub.20 --Monoenaldehyde aus den Plasmalogenen menschlicher Placenten" Hoppe-Seyler's Z. Physiol. Chem. (1970) 351: 179-183.
E. Klenk et al., "Uber die Aldehyde der Glycerinphosphatide des Skelett- und Herzmuskels" Hoppe-Seyler's Z. Physiol. Chem. (1952) 290: 246-251.
E. Klenk & M. Doss, "Uber das Vorkommen von Estercerebrosiden im Gehirn" Hoppe-Syler's Z. Physiol. Chem. (1952) 346: 296-298.
E. Klenk & J.P. Lohr, "Uber die Estercerebroside des Gehirns" Hoppe-Seyler's Z. Physiol. Chem. (1967) 348: 1712-1714.
Venberg et al., "Sphingosine and its natural compounds. Ix. Possible selective protection of hydroxyl group on galactocerebrosides" Chemical Abstracts (1974) 81: entire abstract.
Manev et al., "Glutamate induced Neuronal Death in Primary Culture of Cerebellar Granule Cells . . . " The Journal of Pharmacology and Experimental Therapeutics (Jan. 1990) 252: No. 1.
A. Lehninger, "The Molecular Basis of Cell Structure and Function" Biochemistry (1970) pp. 189-192.
Robert L. Lester et al., "The Isolation and Partial Characterization of Two Novel . . . ceramide" Journ. of Biol. Chem. (1974) 249: 3388-3394.
Cavaillon et al. Eur. J. Immunol. 1986, 16, 1009-1012.
Hakomori Sen-itiroh
Igarashi Yasuyuki
Levery Steven B.
Nudelman Edward
Sadozai Khalid
Fonda Kathleen K.
The Biomembrane Intstitute
LandOfFree
Plasmalopsychosines and plasmalocerebrosides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Plasmalopsychosines and plasmalocerebrosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Plasmalopsychosines and plasmalocerebrosides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1613949