Plasma substitute including artificial starch and method for the

Details Plasma substitute including artificial starch and method for the Plasma substitute including artificial starch and method for the

1973-11-19

1976-02-10

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

260209R, A01N 928

Patent

active

039378217

ABSTRACT:
A process for preparing a pyrogen-free plasma substitute consisting of treating hydroxyethyl starch having a DS of 0.5 - 0.6 (preferably 0.55) and an intrinsic viscosity of 0.28 - 0.30 with an acid to lower the molecular weight; adjusting it to the desired hydroxyethyl starch having a DS of 0.55 and an intrinsic viscosity of 0.08- 0.14; adding a depyrogen reagent, such as Raney-nickel to it, if necessary, obtaining an isotonic aqueous solution containing 6% of hydroxyethyl starch and other various salts, preferably, adding sodium chloride (0.5%), potassium chloride (0.03%), calcium chloride dihydrate (0.02%), sodium lactate (0.224%), and glucose (1%)(W/V%) to 6% hydroxyethyl starch solution; and then adjusting the pH of the obtained iostonic aqueous solution to 6.2 .+-. 0.5.

REFERENCES:
Dispensatory of the United States of America, 25th ed., published by J.B. Lippincott Co., Phila., 1955, pp. 1194-1195.
Dispensatory of the United States of America, 25th ed., published by J.B. Lippincott Co., Phila., 1955, pp. 1196-1197.
Tamada et al., Chem. Pharm. Bull., Vol. 19, pp. 286-291, Feb. 1971.

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