Plasma protein concentrates of reduced thrombogenicity and their

Details Plasma protein concentrates of reduced thrombogenicity and their Plasma protein concentrates of reduced thrombogenicity and their

1982-04-28

1984-05-08

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

044474164

ABSTRACT:
Plasma concentrates of vitamin-K dependent clotting factors of reduced thrombogenic potential useful for clinical replacement therapy in deficiency diseases of these clotting factors are provided. Preferably, concentrates substantially devoid of zymogens extraneous to the deficient factor are employed.

REFERENCES:
Curling, ed.-Methods of Plasma Protein Fractionation (Academic Press) 1980 pp. 60-61.
Suomela et al.-Chem. Abst. vol. 87 (1977) p. 51425w.
Liautaud et al.-Chem. Abst. vol. 94, (1981) p. 109,335e.
Suomela-Chem. Abst. vol. 86, (1977) p. 40,873u.
Yoshiok-Chem. Abst. vol. 89 (1978), pp. 213,384c.
Johnson et al.-Chem. Abst. vol. 95 (1981) p. 49245j.
Tanabe-Chem. Abst. vol. 93 (1980), p. 53851d.
VuKovich et al.-Chem. Abst. vol. 93 (1980), p. 40,663v.
Monahan et al.-Chem. Abst. vol. 94 (1981), p. 2528t.
Aronson, et al., "Toxicity of Factor IX Concentrates in Mice", Develop. Biol. Standard., 44, 185-188 (1979).
Menache, "Prothrombin Complex Concentrates: Clinical Use", Anal. N.Y. Acad. Sci., 370, 747-756 (1981).
Coan, et al., "Properties of Commercial Factor IX Concentrates", Anal. N.Y. Acad. Sci., 370, 731-746 (1981).

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