Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2005-10-11
2005-10-11
Leary, Louise N. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
C435S004000, C435S029000, C435S023000, C435S024000, C514S310000
Reexamination Certificate
active
06953671
ABSTRACT:
This invention provides methods of decreasing apolipoprotein B-containing lipoprotein and of treating atherosclerotic diseases and dyslipidemic diseases by reducing plasma phospholipid transfer protein activity, and methods of identifying chemical compounds for use in such treatments.
REFERENCES:
patent: 5610019 (1997-03-01), Day et al.
patent: 5919795 (1999-07-01), Chang et al.
Notification of Transmittal of International Preliminary Examination Report issued by International Preliminary Examining Authority on Dec. 10, 2003 in connection with related International Application No. PCT/US02/05694.
Ginsberg, H.N. Role of lipid synthesis, chaperone proteins and proteasomes in the assembly and secretion of apoprotein B-containing lipoproteins from cultured liver cells.Clin. Exp. Pharmacol. Physiol.24, A29-32 (1997).
Goldstein, J.L., & Brown, M.S. Familial hypercholesterolemia. In The Metabolic Basis of Inherited Disease. C.R. Scriver, A.R. Beaudet, W.S. Sly, D. Valle, J.B. Stanbury, J.B. Wyngaarden and D.S. Frederickson, editors, McGraw-Hill, New York, 1215-1250 (1989).
Hamilton, R.L. et al. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency.J. Lipid Res.39, 1543-1557 (1998).
Havel, R.J. & Kane, J.P. Introduction: structure and metabolism of plasma lipoproteins. In The Metabolic Basis of Inherited Disease. Scriver, C. R. Beaudet, A.R. Sly, W.S. Valle, D. Standbury, J.B. Wyngaarden, J.B. & Frederickson, D.S. editors McGraw-Hill, New York, 1129-1138 (1989).
Jiang, X. -C. et al. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels.J. Clin. Invest.103, 907-914 (1999).
Kane, J.P. & Havel R.J. Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In The Metabolic Basis of Inherited Disease. C.R. Scriver, A.R. Beaudet, W.S. Sly, D. Valle, J.B. Standbury, J.B. Wyngaarden and D.S. Frederickson, editors, McGraw-Hill, New York, 1139-1164 (1989).
Mahley, R.W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.Science240, 622-630 (1988).
Okamoto, H. et al. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits.Nature496, 203-207 (Jul., 2000).
Plump, A.S. et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.Cell71, 343-353 (1992).
Plump, A.S. & Breslow, J.L. Apolipoprotein E and the apolipoprotein E-deficient mouse.Annu. Rev. Nutr.15, 495-518 (1995).
Tall, A.R. Plasma lipid transfer proteins.Annu. Rev. Biochem.64, 235-257 (1995).
Tall, A.R., Abreu, E. & Shuman, J. Separation of a plasma phospholipid transfer protein from cholesteryl ester/phospholipid exchange protein.J. Biol. Chem.258, 2174-2180 (1983).
Twisk, J. et al. The role of the LDL receptor in apolipoprotein B secretion.J. Clin. Invest.105(4), 521-532 (2000).
Wetterau, J.R. et al. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia.Science258, 999-1001 (1992).
Young, S.G. Recent progress in understanding apolipoprotein B.Circulation82, 1574-1594 (1990).
Zhang, S.H. et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E.Science258, 468-471 (1992).
Jiang Xian-Cheng
Tall Alan R.
Cooper & Dunham LLP
Leary Louise N.
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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