Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Elemental chlorine or elemental chlorine releasing inorganic...
Patent
1998-02-17
2000-08-29
Prats, Francisco
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Elemental chlorine or elemental chlorine releasing inorganic...
424677, 424678, 424679, 424680, 424681, 435 12, 435 13, 435404, 514 23, 514708, A61K 3314, A61K 31715, A01N 5908, A01N 102
Patent
active
06110504&
ABSTRACT:
An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, and albumin which is buffered by lactate and has a pre-administration pH of between 5 and 6.5 is disclosed. Also disclosed is an artificial plasma-like solution having at least two water soluble polysaccharide oncotic agents one of which is eliminated from the circulation slowly and the other of which is eliminated from the circulation quickly. Supplimentation of the plasma-like solution with certain ions is described. A system for administration of the plasma-like solution to a subject wherein the system comprises a first and second solution each having particular buffers is described. The plasma-like solution including cryoprotective adducts is also disclosed. The use of the plasma-like solution in organ transplant, novel chemotherapy procedures, and tissue, organ and organism cryopreservation are also disclosed.
REFERENCES:
patent: 3356570 (1967-12-01), Butcher
patent: 3758382 (1973-09-01), Knorpp
patent: 4663166 (1987-05-01), Veech
patent: 4923442 (1990-05-01), Segall et al.
patent: 5130230 (1992-07-01), Segall et al.
patent: 5252213 (1993-10-01), Ahmad et al.
patent: 5747071 (1998-05-01), Segall et al.
Belzer et al., "Combination Perfusion-Cold Storage for Optimum Cadaver Kidney Function and Utilization" Transplantation (1985) 39(2):118-121.
Bishop et al., "Evaluation of Hypertonic Citrate Flushing Solution for Kidney Preservation Using the Isolated Perfused Rat Kidney" Transplantation (1978) 25(5):235-239.
Carpenter et al., J. Dairy Sci. (1990) 73:3627-3636.
Davidsohn et al (eds.) Clinical Diagnosis by Laboratory Methods, 15th Ed., (1974), Appendix 3, pp. 1376-1382.
Collins, "Hypothermic Kidney Storage" Transplant. Proc. (1977) 9(3):1529-1534.
Fischer et al. "Flush Solution 2, A New Concept for One-to-Three Day Hypothermic Renal Storage Preservation" Transplantation (1985) 39(2):122-126.
Kallerhoff et al., "Effects of Preservation Conditions and Temperature on Tissue Acidification in Canine Kidneys" Transplantation (1985) 39(5):485-489.
Ross et al. "72-HR Canine Kidney Preservation Without Continuous Perfusion" Transplantation (1976) 21(6):498-501.
Sprung et al., "Effects of Acute Hypothermia and b-Adrenergic Receptor Blockade on Serum Potassium Concentration in Rats" Critical Care Medicine (1991), 19(12):1545-51.
Wall et al., "Simple Hypothermic Preservation for Transporting Human Livers Long Distances for Transplantation" Transplantation (1977) 23(3):210-216.
Segall Judith M.
Segall Paul E.
Sternberg Hal
Waitz Harold D.
BioTime, Inc.
Field Bret E.
Prats Francisco
LandOfFree
Plasma-like substance does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Plasma-like substance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Plasma-like substance will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1246988