Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
2006-06-02
2011-11-22
Saucier, Sandra (Department: 1657)
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
active
08062837
ABSTRACT:
The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
REFERENCES:
patent: 4735726 (1988-04-01), Duggins
patent: 5004681 (1991-04-01), Boyse et al.
patent: 5102783 (1992-04-01), Alkemade et al.
patent: 5192553 (1993-03-01), Boyse et al.
patent: 5372581 (1994-12-01), Anderson
patent: 5415665 (1995-05-01), Hessel et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5580714 (1996-12-01), Polovina
patent: 5789147 (1998-08-01), Rubinstein et al.
patent: 5916602 (1999-06-01), Klaus
patent: 5928214 (1999-07-01), Rubinstein et al.
patent: 5993387 (1999-11-01), Moore et al.
patent: 6037174 (2000-03-01), Smith et al.
patent: 6461645 (2002-10-01), Boyse et al.
patent: 6569427 (2003-05-01), Boyse et al.
patent: 6605275 (2003-08-01), Boyse et al.
patent: 2003/0039952 (2003-02-01), Peled
patent: 2003/0161818 (2003-08-01), Weiss et al.
patent: 2003/0180269 (2003-09-01), Hariri
patent: 2003/0215942 (2003-11-01), Chow et al.
patent: 2004/0071666 (2004-04-01), Ferrara et al.
patent: 2004/0197310 (2004-10-01), Sanberg et al.
patent: 2004/0219136 (2004-11-01), Hariri
patent: 2009/0016997 (2009-01-01), Hathaway et al.
patent: 2010/0189696 (2010-07-01), Sun et al.
patent: 0 343 217 (1996-05-01), None
patent: WO 89/04168 (1989-05-01), None
patent: WO 00/38762 (2000-07-01), None
patent: WO 00/73421 (2000-12-01), None
patent: 03/068172 (2003-08-01), None
patent: WO 2004/096319 (2004-11-01), None
Mamoury et al., “Cord Hemoglobin in Newborns in Correlation with Maternal Hemoglobin in Northeastern Iran”, IJMS 28 (3) : 166-168 (2003).
Clinical Hematology, 7thEdition, Wintrobe et al., eds. publisher Lea & Febiger, 1974, p. 1791.
Ademokun et al., “Umbilical cord blood collection and separation for haematopoietic progenitor cell banking”, Bone Marrow Transplantation 19 : 1023-1028 (1997).
Woods et al., “A Theoretically Optimized Method for Cord Blood Stme Cell Cryopreservation”, J. Hematotherapy & Stem Cell research 12 : 341-350 (2003).
Rubinstein et al., “Processing and Cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution”, PNAS 92 : 10119-10122 (1995).
Armitage, S. et al., “Cord blood banking: volume reduction of cord blood units using a semi-automated closed system,” Bone Marrow Transplantation, 1999, vol. 23, pp. 505-509.
Barker, J. et al., “Transplantation of 2 Partially HLA-matched Umbilical Cord Blood Units to Enhance Engraftment in Adults with Hematologic Malignancy.” Blood, vol. 105 No. 3 (2005).
Bensinger, W. et al., “ABO-Incompatible Marrow Transplants.” Transplantation, vol. 33 No. 4 (1982).
Broxemeyer, Hal E. et al, “Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells,” Proc. Natl. Acad. Sci., 1989, vol. 86, pp. 3828-3832.
Broxmeyer, H.E., et al., “High-efficiency recovery of immature haematopoietic progenitor cells with extensive proliferative capacity from human cord blood cryopreserved for 10 years,” Clin. Exp. Immunol, 1997, vol. 107 (Suppl. 1) pp. 45-53.
Broxmeyer, Hal et al., “High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years,” PNAS, 2003, vol. 100, No. 2, pp. 645-650.
Davey, Sue at al., “The London Cord Blood Bank: analysis of banking and transplantation outcome,” British Journal of Haematology, 2004, vol. 125, pp. 358-365.
Dexter, T.M., et al., “Conditions Controlling the Proliferation of Haemopoietic Stem Cells In Vitro.” J. Cell Physiol, 91:335-344. (1977).
Escolar, M. et al., “Transplantation of Umbilical-Cord Blood in Babies with Infantile Krabbe's Disease.” NEJM, 352; 20. (2005).
Fasouliotis, Sozos et al., “Human unbilical cord blood banking and transplantation: a state of the art,” European Journal of Obstetrics & Gynecology and Reproductive Biology, 2000, vol. 90, pp. 13-25.
Hahn, T. et al., “Infusion of Unwashed Umbilical Cord Blood Stem Cells after Thawing for Allogeneic Transplantation.” Bone Marrow Transplantation, 34:739. (2004).
Hahn, T. et al., “Use of Nonvolume-reduced (unmanipulated after thawing) Umbilical Cord Blood Stem Cells for Allogeneic Transplantation Results in Safe Engraftment.” Bone Marrow Transplantation, 32:145-150. (2003).
Hahn, T. et al., “Cord Blood Stem Cells; Use of nonvolume-reduced (unmainpulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment,” Bone Marrow Transplantation, 2003, vol. 31, pp. 145-150.
Kurtzberg, J. et al., “Placental Blood as a Source of Hematopoietic Stem Cells for Transplantation into Unrelated Recipients.” NEJM, vol. 335 pp. 157-166 (1996).
Laughlin, Mary J. et al., “Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia.” NEJM 351;2265 (2004).
Laughlin, MJ “Umbilical cord blood for allogeneic transplantation in children and adults,” Bone Marrow Transplantation, 2001, vol. 27, pp. 1-6.
Locatelli, F. et al., “Factors Associated with Outcome after Cord Blood Transplantation in Children with Acute Leukemia.” Blood, vol. 93 No. 11 (1999).
Nagamura-Inoue, T., et al., “Wash-out DMSO does not improve the speed of Engraftment of Cord Blood Transplantation: Follow-up of 46 Adult Patients with units Shipped from a single Cord Blood Bank.” Transfusion, vol. 43 (2003).
Rocha, V. et al., “Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia.” NEJM, 351:22 (2004).
Sauer-Heilborn, A. et al., “Patient Care During Infusion of Hematopoietic Progenitor Cells.” Transfusion, vol. 44. pp. 907-916 (2004).
Smith, S. et al., “The Influence of Oxygen Tension on the Long-term growth in vitro of Haematopoietic Progenitor cells from Human Cord Blood.” British Journal of Haematology, 63: 29-34 (1986).
Vicente, D. et al., “Progenitor cells Trapped in Marrow Filters can Reduce GvHD and Transplant Mortality.” Bone Marrow Transplantation, 38: 111-117 (2006).
Wagner, J. et al., “Transplantation of Unrelated Donor Umbilical Cord Blood in 102 Patients with Malignant and Nonmalignant Diseases: Influence of CD34 cell dose and HLA Disparity on Treatment-related Morality and Survival.” Blood, vol. 100 No. 5 (2002).
Whitlock, C. et al., “Long-term Culture of B Lymphocytes and their Presursors from Murine Bone Marrow.” Proc. Natl. Acad. Sci. USA vol. 79, pp. 3608-3612 (1982).
Ballen, Karen K., “New trends in umbilical cord blood transplantation,” Blood, 2005, vol. 105, No. 10, pp. 3786-3792.
Chow et al., “Clinical Outcome of Hematopoietic Stem Cell Transplantation (HSCT) using plasma depleted umbilical cord blood units (UCB) that were not depleted of red blood cells prior to cryopreservation,” Blood, 2005, vol. 106, No. 11, pp. 578A-579A.
Chow et al., “Hematopoietic Stem Cell Transplantation (HSCT) for Benign Indications Using Umbilical Cord Blood Units (UCB) That Were Depleted of Plasma, but Not of Red Blood Cells.” Blood, 2005, vol. 106, No. 11, pp. 451B-452B.
Meyer, E.A., et al., “Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Progr
Kilpatrick Townsend & Stockton LLP
Saucier Sandra
StemCyte, Inc.
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