Plasma collecting device

Details Plasma collecting device Plasma collecting device

2001-05-16

2003-12-09

Mancene, Gene (Department: 3751)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C604S263000, C604S197000

Reexamination Certificate

active

06659975

ABSTRACT:

CROSS-REFERENCES TO RELATED APPLICATIONS
This application claims Paris Convention priority of Japanese Application No. 2000-142734 filed May 16, 2000, the complete disclosure of which is hereby incorporated by reference.
FIELD OF THE INVENTION
The present invention relates to a device for collecting plasma from blood vessel instantaneously by drawing and filtering blood continuously.
BACKGROUND OF THE INVENTION
Kind or concentration of blood components, such as metabolites, proteins, lipids, electrolytes, enzymes, antigens and antibodies, is measured, in general, using a plasma or serum sample obtained by centrifuging whole blood. However, centrifuging takes labor and time. Particularly, centrifuging is unsuitable for an urgent case of measuring a small number of samples promptly and on site inspection, because of requiring a centrifuge and electricity. Thereupon, it has been investigated to separate plasma or serum from whole blood by filtration.
Several filtration methods using glass fiber filter have been known wherein whole blood is charged into the glass fiber put in a column from one side of the column, and plasma or serum is obtained from the other side (Japanese Patent KOKOKU Nos. 44-14673, 5-52463, Japanese Patent KOKAI Nos. 2-208565, 4-208856).
However, practical filtration methods capable of obtaining an amount of plasma or serum from whole blood necessary for measuring by an automatic analyzer have not been developed except a part of items, such as blood sugar.
On the other hand, inventors belonging to the assignee of this application have developed a plasma or serum filtering unit comprising a filter element containing a combination of glass fiber filter and porous membrane and a baffle narrowing aperture of the filter element at an exit of a filtrate passage, with which plasma or serum can be separated effectively even from a small quantity of whole blood (U.S. Pat. No. 5,979,669).
Further, these inventors have developed a blood-filtering unit comprising a injection needle for drawing blood at an inlet of the blood-filtering unit and a filtrate receiver connected to an exit of a filtrate passage (U.S. Pat. No. 5,996,811).
But the unit was unsatisfactory for practical use in terms of uneasy operation or handling, since it required a sucking adaptor or syringe connected with the blood-filtering unit to collect and filter blood instantaneously.
Further, a device comprising a vacuum blood-drawing tube containing a injection needle at a front edge of it and accommodating a blood-filtering unit in it, a vacuum tube to suck in filtered serum or plasma, and a part with two injection needles connecting the vacuum blood-drawing tube and the vacuum tube has been developed to separate serum or plasma from whole blood (Japanese Patent KOKAI Nos. 4-208856, 5-93721, 5-188053).
But operation of this device is troublesome too. Because three injection needles contained in the device must be stung in correct order to connect four parts of the device.
SUMMARY OF THE INVENTION
An object of the invention is to provide a device capable of collecting plasma for analysis from blood vessel instantaneously by drawing and filtering blood continuously.
The present inventors investigated in order to solve the aforementioned problems, and they invented a plasma-collecting device comprising a blood-filtering unit having two injection needles connected to each of its two openings, a vacuum blood-drawing tube, and an expanding and contracting element connecting the blood-filtering unit and the vacuum blood-drawing tube.
After one of the injection needles stings into blood vessel, the other injection needle breaks into the vacuum blood-drawing tube by pressure to conduct suction and filtration of blood continuously. Thus, a plasma sample is obtained readily and reliably using the plasma-collecting device according to the present invention.


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patent: 6383818 (2002-05-01), Arai et al.
patent: 5-93721 (1993-04-01), None

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