Plaque inhibition with antiplaque oral composition dispensed fro

Details Plaque inhibition with antiplaque oral composition dispensed fro Plaque inhibition with antiplaque oral composition dispensed fro

1992-08-18

1994-01-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Dentifrices

424 52, 424 57, 424 58, 206277, 2065241, 2065243, 222107, 514718, 514721, 514900, 514901, 514902, A61K 716

Patent

active

052798135

ABSTRACT:
An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. The oral composition preferably contains a tooth hardening proportion of a source of fluoride ions, an anti-tartar proportion of a polyphosphate, a stabilizing proportion (in conjunction with the fluoride source) for the polyphosphate, of a polyvinyl methyl ether-maleic anhydride copolymer, and normal adjuvants for the oral preparation. A method for inhibiting development of plaque on teeth is also within the invention, as is a cleaning article containing an effective amount of the invented dentifrice.

REFERENCES:
patent: 4624679 (1986-11-01), McEntee
patent: 4716034 (1987-12-01), Schelm
patent: 4716036 (1987-12-01), Schelm

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