Plaque-inhibiting oral and dental care preparations

Details Plaque-inhibiting oral and dental care preparations Plaque-inhibiting oral and dental care preparations

1992-02-14

1993-01-26

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

424 56, 424 57, A61K 716

Patent

active

051821001

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

1. Field of the Invention
This invention relates to the use of sulfophosphoric acid ester salts as plaque-inhibiting agents in oral and dental care preparations having an improved anti-plaque effect.
2. Statement of Related Art
Oral and dental care preparations are products which are used to clean and care for the teeth, the oral cavity and the throat. In addition to eliminating halitosis and tooth coatings, their function is to prevent diseases of the teeth and gums, particularly caries and parodontosis. A prerequisite in this regard generally recognized among experts is protection of the dental enamel against demineralization and inhibition of plaque formation.
It is known that water-soluble organic phosphates are effective to a certain extent in reducing the solubility of apatite and the crystal growth of hydroxyl apatite. However, the compounds are not surface-active. Surface-active compounds of the type used to improve the cleaning effect of oral and dental care preparations, for example sodium lauryl sulfate, do not have a favorable effect in reducing the demineralization of dental enamel or in inhibiting plaque formation.
Surface-active sulfophosphoric acid alkenyl ester salts are known as surfactants having good performance properties, for example high foam stability in hard water, high alkali stability and good wetting power, cf. for example DE-OS 38 02 815. These products are prepared by sulfonation of phosphoric acid mono- and/or diesters of unsaturated fatty alcohols and neutralization with alkali metal hydroxide, ammonia or alkanolamines. German patent application P 38 12 718.0 also describes saturated sulfophosphoric acid alkyl ester salts which may be obtained by sulfonation of phosphoric acid mono- and/or diesters of saturated fatty alcohols with sulfur trioxide and neutralization of the sulfonates with alkali metal hydroxide, ammonia or alkanolamines. Adducts of 1 to 30 mol ethylene oxide with unsaturated or saturated fatty alcohols can also be similarly converted into phosphoric acid mono- and/or diesters and sulfonated.


DESCRIPTION OF THE INVENTION



Summary of the Invention

It has now surprisingly been found that these sulfophosphoric acid ester salts not only have good surface-active properties, they are also highly compatible with mucous membrane and reduce the solubility of hydroxyl apatite and inhibit the growth of hydroxyl apatite crystals under in vitro conditions. Accordingly, there is every prospect that these compounds will prevent the demineralization of dental enamel and counteract the formation of plaque.
The present invention relates to the use of surface-active sulfophosphoric acid ester salts corresponding to general formula I ##STR2## in which R.sup.1 and R.sup.2 independently of one another represent hydrogen or a cation M(.sup.+), in addition to which R.sup.2 may also be a group (OC.sub.n H.sub.2n).sub.x --O--R.sup.3 --SO.sub.3.sup.(-) M.sup.(+), R.sup.3 is an alkylene, hydroxyalkylene or alkenylene group containing 8 to 22 carbon atoms, n=2 or 3, x=0 or a number of 1 to 30 and M(.sup.+) is an alkali metal, ammonium, mono-, di- or trialkanolammonium ion containing 2 to 4 carbon atoms in the alkanol group, as plaque-inhibiting agents in the production of oral and dental care preparations.


DESCRIPTION OF PREFERRED EMBODIMENTS

Surface-active sulfophosphoric acid ester salts corresponding to formula I and processes for their production are known from the publications cited above. Compounds corresponding to formula I in which R.sup.3 is a C.sub.8-22 alkylene or hydroxyalkylene group and mixtures of such compounds are obtained by the process described in DE-OS 38 02 815. Compounds corresponding to general formula I in which R.sup.3 is a (saturated) C.sub.8-22 alkylene group are obtained by the process described in German patent application P 38 12 718.0. The --SO.sub.3 --H-- group is preferably situated at a carbon atom which is directly connected to other carbon atoms (so-called secondary carbon atom).
The oral and dental care preparation

REFERENCES:
patent: 3963832 (1976-06-01), Hashimoto et al.
patent: 4956116 (1990-09-01), Fabry et al.
patent: 5041597 (1991-08-01), Fabry et al.

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