Drug – bio-affecting and body treating compositions – Dentifrices – Ferment containing
Patent
1977-08-03
1979-02-06
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Dentifrices
Ferment containing
424 94, A61K 728
Patent
active
041384768
ABSTRACT:
An oral therapeutic substance is formed by modifying a plaque-dispersing enzyme to control and reduce the occurrence of dental caries and periodontal diseases. In one embodiment, the modification is performed by introducing a suitable complexing reagent in combination with carrier and plaque-dispersing glucanohydrolase molecules to molecularly alter the glucanohydrolase. The modification, while having insignificant effects on the catalytic activity of the enzyme, will increase the binding capability of the enzyme to substances of which the tooth surface is formed. The activity of the enzyme on the tooth surface will therefore be maintained for longer periods of time to combat plaque build-up.
REFERENCES:
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J. Termine et al., Chemical Abstracts 73: 126985a (1970); Calcium phosphate ormation in vitro.
R. Peckauskas et al., Chemical Abstracts 84: 117398m (1976); ESR Investigation of the Binding of Acidic Biopolymers to Synthetic Apatite.
C. Nawrot et al., Chemical Abstracts 85: 107042x; Dental Phophoprotein-induced Formation of Hydroxylapatite During in Vitro Synthesis of Amorphous Calcium Phosphate.
J. Glaimcher et al., Chemical Abstracts 77: 57958n (1972); Role of the Organic Matrices in Mineralization.
K. Grizzuti et al., Chemical Abstracts 80: 3790 (1974); Binding of Calcium and Magnesium Ions to the Phosphoglycoprotein Phosvitin.
L. Wiggins, Chemical Abstracts 75: 101285a (1971); Compositions for use on Teeth to Prevent Caries.
Lamberts Burton L.
Simonson Lloyd G.
Eakin Molly C.
Montanye George A.
Roberts Elbert L.
Sciascia Richard S.
The United States of America as represented by the Secretary of
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