Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2008-01-29
2008-01-29
Mehta, Ashwin (Department: 1638)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C536S023600
Reexamination Certificate
active
10475852
ABSTRACT:
A method of increasing methionine and/or methionine related metabolites in a plant is provided. The method is effected by expressing within the plant a cystathionine γ-synthase encoded by a polynucleotide mutated in, or lacking, a region encoding an N-terminal portion of said cystathionine γ-synthase, said region being functional in downregulating an activity of said cystathionine γ-synthase in the plant.
REFERENCES:
patent: 5912414 (1999-06-01), Falco et al.
patent: 6127600 (2000-10-01), Beach et al.
patent: 2004/0142215 (2004-07-01), Barbir et al.
patent: 0485970 (1992-05-01), None
patent: WO 95/31554 (1995-11-01), None
Kim J. et al. Cloning and analysis of the gene for cystathionine gamma-synthase fromArabidopsis thaliana. Plant Mol Biol. Dec. 1996;32(6):1117-24.
Chiba et al. 1999, Science 286:1371-1374.
Berrocal-Lobo et al. 2002, Plant J 29:23-32.
Inaba et al. 1994, Plant Physiol. 104:881-887.
Shaul et al, “Threonine Overproduction in Transgenic Tobacco Plants Expressing a Mutant Desensitized Asparate Kinase ofEscherichia coli”, Plant Physiol., 10:1157-1163, 1992.
Galili, G., “Regulation of Lysine and Threonine Synthesis”,The Plant Cell, 7:89-906, 1995.
Bartlem et al, “Mutation in the Threonine Synthase Gene Results in an Over-Accumulation of Soluble Methionine inArabidopsis”, Plant Physiol., 123:101-110, 2000.
Kim et al, “Repression of Cystathionine γ-Synthase inArabidopsis thalianaProduces Partial Methionine Auxotrophy and Developmental Abnormalities”,Plant Science, 151:9-18, 2000.
Chiba et al, “Evidence for Autoregulation of Cystathionine γ-Synthase mRNA Stability inArabidopsis”, Science, 286:1371-1374, 1999.
Belbahri et al, “Diferent Expression of anS-Adenosylmethionine Synthetase Gene in Transgenic Tobacco Callus Modifies Alkaloid Biosynthesis”,Biotechnology and Bioengineering, 69(1):11-20, 2000.
Pimenta et al, “S-Adenosyl-L-Methionine:L-MethionineS-methyltransferase From Germinating Barley”,Plant Physiol., 118:431-438, 1998.
Thompson et al, “Methionine Synthesis inLemna; Inhibition of Cystathionine γ-Synthase By Propargylglycine”,Plant Physiol., 70:1347-1352, 1982.
Datko et al, “Methionine Biosynthesis inLemna: Inhibitor Studies”,Plant Physiol., 69:1070-1076, 1982.
Tang et al, “A Novel Composite Locus ofArabidopsisEncoding Two Polypeptides with Metatabolically Related But Distinct Functions in Lysine Catabolism”,The Plant Journal, 23(2):195-203, 2000.
Karchi et al, “Seed-Specific Expression of a Bacterial Desensitized Aspartate Kinase Increases the Production of Seed Threonine and Methionine in Transgenic Tobacco”,The Plant Journal, 3(5):721-727, 1993.
Ominato et al, “Identification of a Short Highly Conserved Amino Acid Sequence as the Functional Region Required for Posttranscriptional Autoregulation of the Cystathionine γ-Synthase Gene inArabidopsis”, J. Biological Chemistry, 277(39):36380-36386, 2002.
Hacham et al, “The N-Terminal Region ofArabidopsisCystathionine γ-Synthase Plays and Important Regulatory role in Methionine Metabolism”,Plant Physiol., 128:454-462, 2002.
Anderson, JW, “Sulfur Metabolism in Plants”, Chapter 8 in:The Biochemistry of Plants, vol. 16, p. 327-381, Academic Press, 1990.
Gavish-Galilee Bio Applications Ltd.
Mehta Ashwin
Zheng Li
LandOfFree
Plants characterized by an increased content of methionine... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Plants characterized by an increased content of methionine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Plants characterized by an increased content of methionine... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3934397