Plant tubby-like proteins

Details Plant tubby-like proteins Plant tubby-like proteins

2008-01-01

2008-01-01

Bui, Phuong T (Department: 1638)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S320100, C435S419000, C800S289000, C800S295000, C536S023600

Reexamination Certificate

active

07314756

ABSTRACT:
An isolated polypeptide containing an amino acid sequence at least 70% identical to SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11, and an isolated nucleic acid encoding the polypeptide are disclosed. Disclosed is an isolated nucleic acid that, under stringent conditions, hybridizes to a probe containing SEQ ID NO:20; or its complementary sequence. Also disclosed are (1) a transformed cell or a transgenic plant containing such a nucleic acid and (2) a transformed cell or a transgenic plant lacking the polypeptide encoded by the nucleic acid. Also within the scope of the invention are methods for making the transformed cells or transgenic plants.

REFERENCES:
Lin et al. (NCBI, GenBank, Sequence Accession No. AC011623, pp. 1-37, Published Oct. 2002).
Maniatis et al. (Cold Spring Harbor Laboratory, Chapter 12, pp. 404-421, New York, 1982).
Lin et al. (NCBI, GenBank, Sequence Accession No. AC011623, pp. 1-37, Published Nov. 1999, updated in Jan. 2001).
Sandra Santagata et al. “G-Protein Signaling Through Tubby Proteins”. Science 292:2041-2050, Jun. 15, 2001.
Charles A. Lewis et al. “Tubby-like Protein 1 Homozygous Splice-Site Mutation Causes Early-Onset Severe Retinal Degeneration”. Invest Ophthalmol Vis Sci 40:2106-2114, 1999.
Jennifer M. Gagne et al. “The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes inArabidopsis”. PNAS 99(17):11519-11524, Aug. 20, 2002.
Titus J. Boggon et al. “Implication of Tubby Proteins as Transcriptional Factors by Structure-Based Functional Analysis”. Science 286:2119-2125, Dec. 10, 1999.
Michael A. North et al. “Molecular characterization ofTUB, TULP1,andTULP2, members of the novel tubby gene family and their possible relation to ocular diseases”. Proc. Natl. Acad. Sci. USA 94:3128-3133, Apr. 1997.
Patrick W. Kleyn et al. “Identification and Characterization of the Mouse Obesity Genetubby: A member of a novel gene family”. Cell 85:281-290, Apr. 19, 1996.
Sakae Ikeda et al. “Cell-Specific Expression of Tubby Gene Family MembersTub, Tulp1, 2, and 3) in the Retina”. Invest Ophthalmol Vis Sci 40:2706-2712, 1999.
Akihiro Ikeda et al. “The tubby-like proteins, a family with roles in neuronal development and function”. Journal of Cell Science 115:9-14, 2002.
Patsy M. Nishina et al. “Molecular chracterization of a novel tubby gene family member, TULP3, in the mouse and humans”. Genomics 54:215-220, 1998.

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