Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-06-06
1998-09-15
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514558, 4241951, A61K 3123, A61K 3120, A61K 3578
Patent
active
058078932
ABSTRACT:
By this invention, further properties and uses of plant medium chain thioesterases are provided. In particular, it is now seen that plant seed which would not normally contain medium-chain fatty acid, either as free fatty acids or incorporated into triglyceride molecules, can be found to contain such medium-chain fatty acids. By seed which would not normally contain medium-chain fatty acid is meant seed which contains less than 0.1 mole percent of a given medium-chain fatty acid in total fatty acids. Thus, any plant seed containing a minimum of 1.0 mole percent of a given medium-chain fatty acid in total fatty acids is significantly modified. In one embodiment, this invention relates to plant seed and oil derived from that seed, which normally do not contain laurate, but now are found to contain laurate.
REFERENCES:
patent: 4386111 (1983-05-01), Heteren et al.
patent: 4410557 (1983-10-01), Miller
patent: 4614663 (1986-09-01), Rule
patent: 4721626 (1988-01-01), Rule
Daulatabad, C., et al., "Studies on Verbenaceae Seed Oils," Chem Abstracts (1990) 112:345 No. 232551q.
Poulose, et al., "Cloning and Sequencing of the cDNA for S-Acyl Fatty Acid Synthase Thioesterase from the Uropygial Gland of Mallard Duck," J. of Bio. Chem. (1985) 260(29):15953-15958 Davies, et al., Developmental Induction, Purification, and Further Characterization of 12:0-ACP Thioesterase from Immature Cotyledons of Umbellularia californica, Archives of Biochem. and Biophy. (1991) 290(1) : 37-45.
Naggert, et al., "Cloning and Sequencing of the Medium-Chain S-acyl Fatty Acid Synthetase Thioester Hydrolase cDNA From Rat Mammary Gland," Biochem. J. 243:597-601.
Pollard, et al., "Fatty Acid Synthesis in Developing Oilseeds," Plant Lipids (1987) 455-463.
Cao, et al., "Acyl Coenzyme A Preference of Diacylglycerol Acyltransferase from the Maturing Seeds of Cuphea, Maize, Rapeseed and Canola," Plant Physiol. (1987)84:762-765.
Knauf, Vic C., "Genetic Engineering of Oil Composition in Rapeseed," Cell Biochem. Suppl 16F. (1992) p. 201 Abstract Y012.
Voelker, et al., "Production of Medium-Chain Fatty Acids in Transgenic Oilseeds," Plant Physiology, Supp. (1992) vol. 99, No. 1, p. 76, Abstract 455.
Voelker, et al., "Engineering Laurate Production in Oilseeds," Advances in Gene Technology: Feeding the World in the 21st Century, Biotechnology, vol. 10, No. 1 (1992), p. 59 and Miami Short Reports (1992) Miami Winter Symp. Jan. 19-24, vol. 2, p. 102.
Bayley, et al., "Metabolic Consequences of Expression of the Medium Chain Hydrolase Gene of The Rat In Mouse NIH 3T3 Cells," Bio/Tech (1988) 6:1219-1221.
Downey, et al., "Genetic Control of Fatty Acid Composition In Oilseed Crops," Proceedings of the Flax Institure USA (1971) 41(3):1-3.
Knauf, et al., "Reprogramming Levels of Fatty Acid Synthesis Enzymes In Developing Embryos of Rapeseed, " J. Cell Biochem. Suppl. (1990) 14E:266.
Bafor, et al., "Properties of the Glycerol Acylating Enzymes in Microsomal Preparations from the Developing Seeds of Safflower (Carthamus tinctorius) and Turnip Rape (Brassica campestris) and their Ability to Assemble Cocoa-Butter Type Fats," JAOCS (1990) 67(4) :217-225.
Battey, et al., "Genetic engineering for plant oils: potential and limitation," TIBTECH (1989) 7:122-126.
Knauf, V., "The application of genetic engineering to oilseed crops," TIBTECH (1987) 5:40-47.
McKeon, et al., "Purification and Characterization of the Stearoyl-acyl Carrier Protein Desaturase and the Acyl-acyl Carrier Protein Thioesterase from Maturing Seeds of Safflower," J. of Biol. Chem. (1982) 257(20) :12141-12147.
Pollard, et al., "A Specific Acyl-ACP Thioesterase Implicated in Medium-Chain Fatty Acid Production In Immature Cotyledons of Umbellularia californica," Arch. of Biochem. and Biophys. (1991) 284(2):306-312.
Pollard, Figures 1 through 5 representing information presented as slides at the Seventh International symposium on Plant Lipids, held Jul. 27 -Aug 1, 1986 at the University of California, Davis, California.
Davies, et al., "Developmental Induction, Purification and Further Characterization of 12:0-ACP Thioesterase from Immature Cotyledons of Umbellularia californica," Arch. of Biochem. and Biophys. (1991) 290(1) : 37-45.
Davies Huw Maelor
Voelker Toni Alois
Rollins John W.
Scherer Donna E.
Schwedler Carl J.
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