Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-11-22
1999-03-02
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 64, 536 2, 536123, 5361231, 436 79, 436 82, A61K 31715, C07H 100, G01N 3320
Patent
active
058771646
ABSTRACT:
The present invention provides rhamnogalacturonan-II (RG-II) and relates to its ability to complex specific multivalent heavy metal cations. In the presence of boric acid, RG-II monomers form dimers that are cross-linked by a borate ester. The yield of such borate ester cross-linked dimers of RG-II is enhanced in the presence of specific heavy metal cations. The present invention further relates to the utility of RG-II in assays for the detection of specific heavy metal contamination; as a reagent useful in the removal of specific heavy metal cations contaminating foods and liquids, for example, fish, wines, etc.; as a pharmaceutical composition useful as an antidote in specific heavy metal cation poisoning; as a treatment for the detoxification of specific heavy metal cations from blood and/or tissues; and in a method of remediation of waters and soils contaminated with specific heavy metal cations.
REFERENCES:
Kobayashi et al. "Boron Nutrition of Cultured Tobacco BY-2 Cells. II. Characterization of the Borno-Polysaccharide Complex" Plant Cell Physiol. 38(6): 676-683 (1997).
Kobayashi et al. "Two Chains of Rhamnogalacturonan II Are Cross-Linked by Borate-Diol Ester Bonds in Higher Plant Cell Walls" Plant Physiol. 110:1017-1020 (1996).
O'Neill et al. J. Biol. Chem. Sep. 13, 1996, 271(37), 22923-30.
Matoh et al. Plant Cell Physiol. 1993, 34(4), 639-42.
Pellerin et al. Carbohydrate Research 1996, 290(2), 183-97.
Albersheim Peter
Darvill Alan G.
O'Neill Malcolm A.
Pellerin Patrice J. M.
Vidal Stephane
Fonda Kathleen K.
Institute National de la Recherche Agronomique
University of Georgia Research Foundation Inc.
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