Plant extracts and alkaloids having antitussive activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C540S581000, C540S586000

Reexamination Certificate

active

06992078

ABSTRACT:
The present invention provides plant extracts, isolated alkaloids, synthetic alkaloids and compositions having antitussive activity. In some preferred embodiments, the plant extracts and the isolated alkaloids are from a plant of a genus in the familyStemonaceae.In other preferred embodiments, the plant extracts and the isolated alkaloids are from a plant of the genusStemona, Croomia,orStichoneuron.In especially preferred embodiments, the plant extracts and the isolated alkaloids are from the plantStemona tuberosa.The present invention further provides methods for isolating such plant extracts and alkaloids. In addition, the present invention provides methods for reducing or suppressing coughing by administering plant extracts, alkaloids and compositions having antitussive activity.

REFERENCES:
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CAPLUS printout of Pfeifer et al., Alkaloids of Vietnamese Stemona Tuberosa, Pharmazie, vol. 23, No. 6, pp. 342-343, 1968.
CAPLUS printout of Ye et al., Alkaloids from Tuberosa, Phytochemistry, vol. 37, No. 4, pp. 1201-1203, 1994.
CAPLUS printout of Pham et al., Alkaloids from Stemona Collinsae, Journal of Asian Natural Products Research, vol. 4, No. 2, pp. 81-85, 2002.
Changying, Zou et al.; “New alkaloids from the roots ofStemona japonicaMiq.”;Journal of Chinese Pharmaceutical Sciences; 1999; pp. 185-190; vol. 8, No. 4.
Dao, C. Ngoan et al.; “Tuberostemonine L-G”;Acta Cryst.; 1994; pp. 1612-1615; vol. C50; International Union of Crystallography.
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Pham, Huu Dien et al.; “Alkaloids from VietnameseStemona tuberosaLour(Stemonaceae) Part 1; Neotuberostemonine and bisdehydroneotuerostemonine (Translation of title)”;Tao Chi Hoa Hoc; 2000; pp. 64-67; vol. 38, No. 1 [In Vietnamese].
Pilli, Ronaldo Aloise and Maria Da Conceiçäo Ferreira de Oliveira; “Recent progress in the chemistry of theStemonaalkaloids”;Nat. Prod. Rep.; 2000; pp. 117-127; vol. 17; The Royal Society of Chemistry .
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Wen-Han, Lin, et al.; “Chemical studies on newStemonaalkaloids, IV. Studies on new alkaloids fromStemona tuberosa”;Journal of Natural Products; 1992; pp. 571-576; vol. 55, No. 5.
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