Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1996-06-03
1998-03-10
Lankford, Jr., Leon B.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
425404, 425405, A01N 6500, A61K 3578
Patent
active
057258597
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention concerns a plant-based pharmaceutical agent having an antiviral, anti-allergic and virustatic effect.
2. Description of the Prior Art
The herpes simplex viruses (HSV) belong to the group of DNA viruses. Of about 70 different serological sub-types six are of importance in causing disease in humans. These are:
The hallmark of this group of viruses are the frequent recurring of disease by the reactivation of the latent virus infection. The reactivation of HSV-1 virus is for example responsible for recurrent attacks of herpes labialis and stomatitis apthosa herpetica. The HSV-2 causes the recurring, disturbing genital herpes and is also brought into relation with the carcinoma of the cervix and HIV-infection. The infectious mononucleosis is only one of the infections caused by the Epstein-Barr virus. The spectrum of EBV infection stretches from a mild subclinical monosymptomatic course to the full picture of mononucleosis. This virus settles down in the cells of the liver, causing an increase in the levels of transaminases and hepatitis. Periodically occurring depressive and anxiety disorders are also brought in association with EBV-reactivation. Cytomegalovirus (CMV) has a high level of contamination (30-40% of the population). Through placenta transmission in the carrier, the CMV can cause malformation. Moreover, infection with this virus leads to fatal pneumonia, myocarditis or hepatitis in immuncompromised hosts with HIV-infection or organ transplantation. Infections caused by hepatitis B and C viruses, which too belong to the DNA-viruses, lead to chronic active hepatitis which end up frequently in liver cirrhosis and liver insufficiency. Allergic rhino-sino-bronchitis are disorders characterized by hyperreactivity of the mucous membrane with the resulting edema of the respiratory tract. It is known to-day that also here, in many cases, viral infects prolong the lowering of the allergic or the "asthmatic" threshold of the respiratory tract.
No curative treatment for these diseases is available so far. They are treated either prophylactically (e.g. immunglobulines) or, whenever possible, purely symptomatically. A chemotherapy against HSV viruses and hepatitis B and hepatitis C viruses has been so far of little success. The reason for this lies among others, in the cytotoxicity of the newly discovered antiviral substances. The antiviral substances known so far (e.g. aciclovir) exhibit their virustatic activity only in the proliferative phase and not in the latent phase thus they are unable to eradicate the virus. Moreover these therapies are very cost consuming. For example a CMV-disease in immuncompromised host with organ transplantation may cost in USA between $10,000-$50,000. Corticoids and anti-histamines offer a temporary relief against allergic rhino-sino-bronchitis. Also these medications are associated with serious, sometimes life threatening side effects. A medical invention with anti-vital and virustatic activity, which is at the same time less costly and free from risks, is therefore highly desirable.
The herbs absinthe, resin of mastic (resin pistacia lenticus, fruit of delphinium denudatum are well-known drugs. Their anti-viral and virustatic activity is unknown so far. The seeds of cardamom (fructus elettaria cardamomum), buds of roses (flores rosae) and flowers of borage (flores onosma brateatum boraginaceae are known as spices and decorative herbs. The invention describes the antiviral and virustatic and anti-allergic activity of absinthe resin of mastic and fruit of delphinium denudatum singly or in combination with rose buds, cardamom seed and flowers of borage.
In order to demonstrate the desired antiviral, virustatic and anti-allergic efficacy following herbs and their mixtures were tested:
These herbs or their mixtures were disinfected with UV light, finely ground and passed through a sieve (less than 1 mm size) and ointment was prepared in association with the usual pharmaceutical carrier substances. For oral administr
Lankford , Jr. Leon B.
Tate Christopher R.
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