Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Reexamination Certificate
2005-06-29
2009-06-02
Chin, Christopher L (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
C422S082050, C422S082110, C435S005000, C435S006120, C435S007200, C435S287200, C435S288700, C436S164000, C436S172000, C436S805000
Reexamination Certificate
active
07541196
ABSTRACT:
An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of CEA is described including injecting a possible CEA-containing sample into a sensor cell including the assay element, maintaining the sample within the sensor cell for time sufficient for binding to occur between CEA present within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.
REFERENCES:
patent: 5830766 (1998-11-01), Attridge et al.
Li Lin
Martinez Jennifer S.
Shively John E.
Swanson Basil I.
Chin Christopher L
Cottrell Bruce H.
Jones Juliet A.
Los Alamos National Security LLC
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