Planar micromixer

Details Planar micromixer Planar micromixer

2008-03-18

2008-03-18

Sines, Brian (Department: 1797)

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

C422S050000, C422S068100, C422S081000, C422S105000

Reexamination Certificate

active

10960324

ABSTRACT:
The present embodiment describes a laminar-mixing embodiment that utilizes simple, three-dimensional injection. Also described is the use of the embodiment in combination with wide and shallow sections of channel to affect rapid mixing in microanalytical systems. The shallow channel sections are constructed using all planar micromachining techniques, including those based on isotropic etching. The planar construction enables design using minimum dispersion concepts that, in turn, enable simultaneous mixing and injection into subsequent chromatography channels.

REFERENCES:
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5904424 (1999-05-01), Schwesinger et al.
patent: 5921678 (1999-07-01), Desai et al.
patent: 6033546 (2000-03-01), Ramsey
patent: 6136272 (2000-10-01), Weigl et al.
patent: 6170981 (2001-01-01), Regnier et al.
patent: 6270641 (2001-08-01), Griffiths et al.
patent: 6623860 (2003-09-01), Hu et al.
patent: 6743636 (2004-06-01), Chung et al.
patent: 7081189 (2006-07-01), Squires et al.
patent: 2001/0048900 (2001-12-01), Bardell et al.
patent: 2003/0086333 (2003-05-01), Tsouris et al.
patent: 2003/0123322 (2003-07-01), Chung et al.
patent: 2003/0198130 (2003-10-01), Karp et al.
patent: 2003/0207338 (2003-11-01), Sklar et al.
patent: 2004/0231990 (2004-11-01), Aubry et al.
Z. H. Fan and D. J. Harrison, “Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections,”Analytical Chemistry,v.66, pp. 177-184, 1994.
S. C. Jacobson, R. Hergenroder, L. B. Koutny, R. J. Warmack, and J. M. Ramsey, “Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices,”Analytical Chemistry,v.66, pp. 1107-1113, 1994.
S. C. Jacobson, C. T. Culbertson, J. E. Daler, and J. M. Ramsey, “Microchip structures for submillisecond electrophoresis,”Analytical Chemistry,v.70, pp. 3476-3480, 1998.
R. H. Liu, M. A. Stremler, K. V. Sharp, M. G. Olsen, J. G. Santiago, R. J. Adrian, H. Aref, and D. J. Beebe, “Passive mixing in a three-dimensional serpentine microchannel,”Journal of Microelectromechanical Systems,v.9, pp. 190-197, 2000.
D. Stroock, M. Weck, D. T. Chiu, W. T. S. Huck, P. J. A. Kenis, R. F. Ismagilov, and G. M. Whitesides, “Patterning electro-osmotic flow with patterned surface charge,”Physical Review Letters,v.84, pp. 3314-3317, 2000.
M. H. Oddy, J. G. Santiago, and J. C. Mikkelsen, “Electrokinetic instability micromixing,”Analytical Chemistry,v.73, pp. 5822-5832, 2001.
S. K. Griffiths and R. H. Nilson, “Low-dispersion turns and junctions for microchannel systems,”Analytical Chemistry,v.73, pp. 272-278, 2001.
B. He, B. J. Burke, X. Zhang, R. Zhang, F. E. Regnier, “A picoliter-volume mixer for microfluidic analytical systems,”Analytical Chemistry,v.73, pp. 1942-1947, 2001.
M. Vazquez, G. McKinley, L. Mitnik, S. Desmarais, P. Matusdaira, and D. Ehrlich, “Electrophoresis using ultra-high voltages,”Journal of Chromatography B,v.779, pp. 163-171, 2002.
J. Kruger, K. Singh, A. O'Neill, C. Jackson, A. Morrison, and P. O'Brien, “Development of a microfluidic device for fluorescence activated cell sorting,”Journal of Micromechanics and Microengineering,v.12, pp. 486-494, 2002.
A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezic, H. A. Stone, and G. M. Whitesides, “Chaotic mixer for microchannels,”Science,v.295, pp. 647-651, 2002.
E. Verpoorte, “Microfluidic chips for clinical and forensic analysis,”Electrophoresis,v.23, pp. 677-712, 2002.
R. Bharadwaj, J. G. Santiago, and B. Mohammadi, “Design and optimization of on-chip capillary electrophoresis,”Electrophoresis,v.23, pp. 2729-2744, 2002.
M. Cabodi, Y.-F. Chen, S. W. P. Turner, H. G. Craighead, and R. H. Austin “Continuous separation of biomolecules by the laterally asymmetric diffusion array with out-of-plane sample injection,”Electrophoresis,v.23, pp. 3496-3503, 2002.
S. Qian and H. H. Bau, “A chaotic electroosmotic stirrer,”Analytical Chemistry,v.74, pp. 3616-3625, 2002.
V. Mengeaud, J. Josserand, and H. H. Girault, “Mixing processes in a zigzag microchannel: finite element simulations and optical study,”Analytical Chemistry,v.74, pp. 4279-4286, 2002.
L.-M. Fu, R.-J. Yang, G.-B. Lee, and H.-H. Liu, “Electrokinetic injection techniques in microfluidic chips,”Analytical Chemistry,v.74, pp. 5084-5091, 2002.
D. Erickson and D. Li, “Microchannel flow with patchwise and periodic surface heterogeneity,”Langmuir,v.18, pp. 8949-8959, 2002.
R. H. Nilson, S. K. Griffiths, and A. K. Singh, “Injection of Sample Bands from Open Channels into Packed Separation Columns,” inProceedings of the mTAS 2002 Symposium, Kluwer Academic Publishers, Boston, MA, v.1, pp. 97-99, 2002.
R. Ashton, C. Padala, and R. S. Kane, “Microfluidic separation of DNA,”Current Opinion in Biotechnology,v.14, pp. 497-504, 2003.
L.-M. Fu, R.-J. Yang, G.-B. Lee, and Y.-J. Pan, “Multiple injection techniques for microfluidic sample handling,”Electrophoresis,v.24, pp. 3026-3032, 2003.
G. J. Fiechtner and E. B. Cummings, “Faceted design of channels for low-dispersion electrokinetic flows in microfluidic systems,”Analytical Chemistry,v.75, pp. 4747-4755, 2003.
L.-M. Fu and C.-H. Lin, “Numerical analysis and experimental estimation of a low-leakage injection technique for capillary electrophoresis,”Analytical Chemistry,v.75, pp. 5790-5796, 2003.
G. J. Fiechtner and E. B. Cummings, “Low-dispersion electrokinetic flow for expanded separation channels in microfluidic systems: multiple faceted interfaces,”Journal of Chromatography A,v.1027, pp. 245-257, 2004.

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