Placenta trophoblast-specific gene

Details Placenta trophoblast-specific gene Placenta trophoblast-specific gene

1998-08-06

2000-05-16

Sisson, Bradley

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 435 6, 435 691, 4352523, 4353201, 436504, C07H 2104

Patent

active

060639121

ABSTRACT:
Expression of the polynucleotide molecule, Psx, is restricted to placenta, and in particular, to placenta trophoblast cell layers during embryogenesis. The expression pattern of Psx is exploited to detect trophoblast specific lineages, such as labyrinthine trophoblast layer and giant cells. The invention provides an isolated DNA molecule encoding Psx protein, and chimeric constructs, vector and host cells containing the isolated DNA. Also provided is a method for identifying putative abortion-inducing agents, which may offer an alternative to surgical abortion.

REFERENCES:
Han et al. (Mar. 3, 1998) "Psx, a Novel Murine Homeobox Gene Expressed in Placenta" Gene 207, pp. 159-166.
Maniatis et al. (1982) Molecular Cloning A Laboratory Manual. Cold Spring Harbor Laboratory, pp. 122-123.
Han et al. (Mar. 19, 1998) Direct Submission, EMBL/GenBank Database, Accession No. AF017453.
Marra et al. (Jul. 8, 1998) The WashU-HHMI Mouse EST Project, EMBL/GenBank/EST Database, Accession No. AI047063.
Kurman, et al., Placenta, 5(1984), pp. 349-370.
Guillemot, et al., Nature, 371(Sep. 22, 1994), pp. 333-336.
El-Refaey, et al., Human Reproduction, 10:2(1995), pp. 475-478.
Cross, et al., Science, 266:2(Dec. 1994), pp. 1508-1518.
Losch, et al., Acta Obstet Gynecol Scand, 75(1996), pp. 753-756.
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Cadepond et al., Annu Rev. Med., 48(1997), pp. 129-156.
Rossant, Developmental Biology, 6(1995), pp. 237-247.
Sapin et al., Developmental Biology, 191(1997), pp. 29-41.
Orwig, et al., Trophoblast Research, 11(1998), pp. 65-85.

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