PKR activation via hybridization chain reaction

Details PKR activation via hybridization chain reaction PKR activation via hybridization chain reaction

2011-06-14

2011-06-14

Schnizer, Richard (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023740, C536S024310, C435S006120

Reexamination Certificate

active

07960357

ABSTRACT:
The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR via RNA-HCR can be used to treat a wide variety of diseases and disorders by specifically targeting diseased cells.

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