PknB kinase and pstP phosphatase and methods of identifying...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S069100, C435S194000, C435S252300, C435S253100, C435S320100, C435S471000, C435S015000, C435S021000, C435S032000, C536S023200

Reexamination Certificate

active

07364856

ABSTRACT:
The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.

REFERENCES:
patent: 2004/0029129 (2004-02-01), Wang et al.
patent: 2006/0019324 (2006-01-01), Alzari et al.
patent: WO 03/074728 (2003-09-01), None
patent: WO 03.074728 (2003-09-01), None
patent: WO 03/074728 (2003-09-01), None
Av-Gay et al., Expression and characterization of theMycobacterium tuberculosisserine/threonine kinase PknB. Infn. Immun. 67(11): 5676-5682, 1999.
Fleischman et al., Whole-Genome comparison ofMycobacterium tuberculosisclinical and laboratory strains. J. Bacteriol., 2002, vol. 184 (19): 5479-5490.
Young et al., Structure ofMycobacterium tuberculosisPknB supports a universal activation mechanism for Ser/Thr protein kinases. Nature Structural Biology, 2003, vol. 10 (3): 168-174. published on line 27 Jan. 2003.
Ortiz-Lombardia et al., Crystal structure of the catalytic domain of the PknB serine/Threonine kinase fromMycobacterium tuberculosis. JBC., 2003, vol. 278 (15): 13094-13100. published on line Jan. 27, 2003.
Av-Gay et al., Expression and characterization of theMycobacterium tuberculosisserine/threonine protein kinase PknB. Infn. Immun. 67(11): 5677-5682, 1999.
Tracy A. Young, et al., “Structure ofMycobacterium tuberculosisPknB supports a universal activation mechanism for Ser/Thr protein kinases”, Nature Structural Biology-Advance online publication, 2003.
Rachna Chaba, et al., “Evidence that a eukaryotic-type serine/threonine protein kinase fromMycobacterium tuberculosisregulates morphological changes associated with cell division”, Eur. J. Biochem, 269, 1078-1085 (2002).
Liang Shi, et al., “The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: a family portrait”, FEMS Microbiology Reviews 22 (1998) 229-253.
Yossef Av-Gay, et al., “Expression and Characterization of theMycobacterium tuberculosisSerine/Threonine Protein Kinase PknB”, Infection and Immunity, Nov. 1999, pp. 5676-5682.
Anil Koul, et al., “Cloning and Characterization of Secretory Tyrosine Phosphatases ofMycobacterium tuberculosis”, Journal of Bacteriology, Oct. 2000, p. 5425-5432.
Tatiana A. Gaidenko, et al., “The PrpC Serine-Threonine Phosphatase and PrkC Kinase Have Opposing Physiological Roles in Stationary-PhaseBacillus subtilisCells”, Journal of Bacteriology, Nov. 2002, pp. 6109-6114.
Anil Koul, et al., “Serine/threonine protein kinases PknF and PknG ofMycobacterium tuberculosis: characterization and localization”, Microbiology (2001), 147, pp. 2307-2314.
Miguel Ortiz-Lombardia, et al., “Crystal Structure of the Catalytic Domain of the PknB Serine/Threonine Kinase fromMycobacterium tuberculosis”, The Journal of Biological Chemistry, vol. 278, No. 15, Issue of Apr. 11, 2003, pp. 13094-13100.
Yossef Av-Gay, et al., “The eukaryotic-like Ser/Thr protein kinases ofMycobacterium tuberculosis”, Trends in Microbiology, vol. 8, No. 5, May 2000.
Mark Pallen, et al., “Bacterial FHA domains: neglected players in the phosphor-threonine signaling game?”, Trends in Microbiology, vol. 10, No. 12, Dec. 2002.
U.S. Appl. No. 10/564,975, filed Jan. 18, 2006, Alzari et al.

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